E70.321 Tyrosinase positive oculocutaneous albinism

Billable ICD-10-CM code, FY2026. Acts as a Complication or Comorbidity (CC) as a secondary diagnosis.

Applicable to

• Albinism II
• Oculocutaneous albinism ty-pos

Applies from E70.32 Oculocutaneous albinism

Excludes1 (never code together)

• Chediak-Higashi syndrome (E70.330)
• Hermansky-Pudlak syndrome (E70.331)

Risk adjustment (HCC)

• CMS-HCC V22: HCC 23 — Other Significant Endocrine and Metabolic Disorders
• RxHCC V08: HCC 43 — Pituitary, Adrenal Gland, and Other Endocrine and Metabolic Disorders
• ESRD V24: HCC 23

MS-DRG index

Defines the logic of DRG(s) 642 in MDC 10.

Approximate ICD-9-CM (GEMs)

• 270.2 Other disturbances of aromatic amino-acid metabolism (approximate)

Code annotations containing back-references to E70.321

Back-references to E70

• Type 1 Excludes: E72 Other disorders of amino-acid metabolism ("aromatic amino-acid metabolism (E70.-)")
• Type 2 Excludes: G11 Hereditary ataxia ("metabolic disorders (E70-E88)")
• Code First: G63 Polyneuropathy in diseases classified elsewhere ("metabolic diseases (E70-E88)")
• Type 2 Excludes: G71 Primary disorders of muscles ("metabolic disorders (E70-E88)")
• Code First: H42 Glaucoma in diseases classified elsewhere ("specified metabolic disorder (E70-E88)")
• Type 2 Excludes: N25.0 Renal osteodystrophy ("metabolic disorders classifiable to E70-E88")
• Type 2 Excludes: N25.81 Secondary hyperparathyroidism of renal origin ("metabolic disorders classifiable to E70-E88")
• Type 1 Excludes: P59 Neonatal jaundice from other and unspecified causes ("jaundice due to inborn errors of metabolism (E70-E88)")
• Type 1 Excludes: R79 Other abnormal findings of blood chemistry ("specific findings indicating disorder of amino-acid metabolism (E70-E72)")
• Type 1 Excludes: R79.83 Abnormal findings of blood amino-acid level ("disorders of amino-acid metabolism (E70-E72)")

Diagnosis Index entries for E70.321

• Albinism, albino › II
• Albinism, albino › oculocutaneous › tyrosinase (ty) positive

Nearby codes

• E70.311 Autosomal recessive ocular albinism
• E70.318 Other ocular albinism
• E70.319 Ocular albinism, unspecified
• E70.32 Oculocutaneous albinism
• E70.320 Tyrosinase negative oculocutaneous albinism
• E70.321 Tyrosinase positive oculocutaneous albinism (this code)
• E70.328 Other oculocutaneous albinism
• E70.329 Oculocutaneous albinism, unspecified
• E70.33 Albinism with hematologic abnormality
• E70.330 Chediak-Higashi syndrome
• E70.331 Hermansky-Pudlak syndrome