E74.12 Hereditary fructose intolerance

Billable ICD-10-CM code, FY2026.

Applicable to

• Fructosemia

Applies from E74 Other disorders of carbohydrate metabolism

Excludes1 (never code together)

• diabetes mellitus (E08-E13)
• hypoglycemia NOS (E16.2)
• increased secretion of glucagon (E16.3)
• mucopolysaccharidosis (E76.0-E76.3)

Applies from E74.1 Disorders of fructose metabolism

Excludes1 (never code together)

• muscle phosphofructokinase deficiency (E74.09)

MS-DRG index

Defines the logic of DRG(s) 391-392 in MDC 06.

Approximate ICD-9-CM (GEMs)

• 271.2 Hereditary fructose intolerance (approximate)

Code annotations containing back-references to E74.12

Back-references to E74

• Type 2 Excludes: G11 Hereditary ataxia ("metabolic disorders (E70-E88)")
• Code First: G63 Polyneuropathy in diseases classified elsewhere ("metabolic diseases (E70-E88)")
• Type 2 Excludes: G71 Primary disorders of muscles ("metabolic disorders (E70-E88)")
• Code First: H42 Glaucoma in diseases classified elsewhere ("specified metabolic disorder (E70-E88)")
• Type 2 Excludes: N25.0 Renal osteodystrophy ("metabolic disorders classifiable to E70-E88")
• Type 2 Excludes: N25.81 Secondary hyperparathyroidism of renal origin ("metabolic disorders classifiable to E70-E88")
• Type 1 Excludes: P59 Neonatal jaundice from other and unspecified causes ("jaundice due to inborn errors of metabolism (E70-E88)")
• Type 1 Excludes: R79 Other abnormal findings of blood chemistry ("specific findings indicating disorder of carbohydrate metabolism (E73-E74)")

Diagnosis Index entries for E74.12

• Disorder (of) › fructose metabolism › hereditary fructose intolerance
• Fructosemia (benign) (essential)
• Intolerance › fructose › hereditary

Nearby codes

• E74.05 Lysosome-associated membrane protein 2 [LAMP2] deficiency
• E74.09 Other glycogen storage disease
• E74.1 Disorders of fructose metabolism
• E74.10 Disorder of fructose metabolism, unspecified
• E74.11 Essential fructosuria
• E74.12 Hereditary fructose intolerance (this code)
• E74.19 Other disorders of fructose metabolism
• E74.2 Disorders of galactose metabolism
• E74.20 Disorders of galactose metabolism, unspecified
• E74.21 Galactosemia
• E74.29 Other disorders of galactose metabolism