G92.05 Immune effector cell-associated neurotoxicity syndrome, grade 5

Billable ICD-10-CM code, FY2026. Acts as a Complication or Comorbidity (CC) as a secondary diagnosis.

Applicable to

• ICANS, grade 5

Applies from G92.0 Immune effector cell-associated neurotoxicity syndrome

Code first

• underlying cause such as:
• complications of immune effector cellular therapy (T80.82)

Code also

• , if applicable, associated signs and symptoms, such as:
• cerebral edema (G93.6)
• unspecified convulsions (R56.9)

MS-DRG index

Defines the logic of DRG(s) 023-024 in MDC 01.

Medicare Code Edits (MCE v43.1 (April 2026))

• Unacceptable principal diagnosis: These codes describe a circumstance which influences care but is not a current illness or injury, or capture only an underlying condition, and are unacceptable as principal diagnosis.

Code annotations containing back-references to G92.05

Back-references to G92.0

• Use Additional: T80.82 Complication of immune effector cellular therapy ("immune effector cell-associated neurotoxicity syndrome (G92.0-)")

Back-references to G92

• Use Additional: G90.81 Serotonin syndrome ("toxic encephalopathy (G92.-)")

Diagnosis Index entries for G92.05

• Syndrome › immune effector cell-associated neurotoxicity (ICANS) › grade › 5

Nearby codes

• G92.00 Immune effector cell-associated neurotoxicity syndrome, grade unspecified
• G92.01 Immune effector cell-associated neurotoxicity syndrome, grade 1
• G92.02 Immune effector cell-associated neurotoxicity syndrome, grade 2
• G92.03 Immune effector cell-associated neurotoxicity syndrome, grade 3
• G92.04 Immune effector cell-associated neurotoxicity syndrome, grade 4
• G92.05 Immune effector cell-associated neurotoxicity syndrome, grade 5 (this code)
• G92.8 Other toxic encephalopathy
• G92.9 Unspecified toxic encephalopathy