K76.81 Hepatopulmonary syndrome

Billable ICD-10-CM code, FY2026.

Code first

• underlying liver disease, such as:
• alcoholic cirrhosis of liver (K70.3-)
• cirrhosis of liver without mention of alcohol (K74.6-)

Applies from K76 Other diseases of liver

Excludes2 (not included here)

• alcoholic liver disease (K70.-)
• amyloid degeneration of liver (E85.-)
• cystic disease of liver (congenital) (Q44.6)
• hepatic vein thrombosis (I82.0)
• hepatomegaly NOS (R16.0)
• pigmentary cirrhosis (of liver) (E83.110)
• portal vein thrombosis (I81)
• toxic liver disease (K71.-)

Risk adjustment (HCC)

• CMS-HCC V28: HCC 63 — Chronic Liver Failure/End-Stage Liver Disorders
• CMS-HCC V22: HCC 27 — End-Stage Liver Disease
• ESRD V24: HCC 27

MS-DRG index

Defines the logic of DRG(s) 205-206 in MDC 04.

Approximate ICD-9-CM (GEMs)

• 573.5 Hepatopulmonary syndrome

Medicare Code Edits (MCE v43.1 (April 2026))

• Unacceptable principal diagnosis: These codes describe a circumstance which influences care but is not a current illness or injury, or capture only an underlying condition, and are unacceptable as principal diagnosis.

Diagnosis Index entries for K76.81

• Syndrome › hepatopulmonary

Nearby codes

• K76.4 Peliosis hepatis
• K76.5 Hepatic veno-occlusive disease
• K76.6 Portal hypertension
• K76.7 Hepatorenal syndrome
• K76.8 Other specified diseases of liver
• K76.81 Hepatopulmonary syndrome (this code)
• K76.82 Hepatic encephalopathy
• K76.89 Other specified diseases of liver
• K76.9 Liver disease, unspecified