R53.1 Weakness

Billable ICD-10-CM code, FY2026.

Applicable to

• Asthenia NOS

Excludes1 (never code together)

• age-related weakness (R54)
• muscle weakness (generalized) (M62.81)
• sarcopenia (M62.84)
• senile asthenia (R54)

MS-DRG index

Defines the logic of DRG(s) 947-948 in MDC 23.

Approximate ICD-9-CM (GEMs)

• 780.79 Other malaise and fatigue (approximate)

Diagnosis Index entries for R53.1

• Asthenia, asthenic
• Weak, weakening, weakness (generalized)

Nearby codes

• R53 Malaise and fatigue
• R53.0 Neoplastic (malignant) related fatigue
• R53.1 Weakness (this code)
• R53.2 Functional quadriplegia
• R53.8 Other malaise and fatigue
• R53.81 Other malaise
• R53.82 Chronic fatigue, unspecified
• R53.83 Other fatigue