R65.10 Systemic inflammatory response syndrome (SIRS) of non-infectious origin without acute organ dysfunction

Billable ICD-10-CM code, FY2026. Acts as a Complication or Comorbidity (CC) as a secondary diagnosis.

Applicable to

• Systemic inflammatory response syndrome (SIRS) NOS

Applies from R65.1 Systemic inflammatory response syndrome (SIRS) of non-infectious origin

Excludes1 (never code together)

• sepsis- code to infection
• severe sepsis (R65.2)

Code first

• underlying condition, such as:
• heatstroke (T67.0-)
• injury and trauma (S00-T88)

Risk adjustment (HCC)

• CMS-HCC V28: HCC 2 — Septicemia, Sepsis, Systemic Inflammatory Response Syndrome/Shock
• CMS-HCC V22: HCC 2 — Septicemia, Sepsis, Systemic Inflammatory Response Syndrome/Shock
• ESRD V24: HCC 2

MS-DRG index

Defines the logic of DRG(s) 864 in MDC 18.

Approximate ICD-9-CM (GEMs)

• 995.93 Systemic inflammatory response syndrome due to noninfectious process without acute organ dysfunction (approximate)

Medicare Code Edits (MCE v43.1 (April 2026))

• Unacceptable principal diagnosis: These codes describe a circumstance which influences care but is not a current illness or injury, or capture only an underlying condition, and are unacceptable as principal diagnosis.

Code annotations containing back-references to R65.10

Back-references to R65.1

• Use Additional: T67.0 Heatstroke and sunstroke ("systemic inflammatory response syndrome (R65.1-)")

Diagnosis Index entries for R65.10

• Syndrome › systemic inflammatory response (SIRS), of non-infectious origin (without organ dysfunction)
• System, systemic › inflammatory response syndrome (SIRS) of non-infectious origin (without organ dysfunction)

Nearby codes

• R65 Symptoms and signs specifically associated with systemic inflammation and infection
• R65.1 Systemic inflammatory response syndrome (SIRS) of non-infectious origin
• R65.10 Systemic inflammatory response syndrome (SIRS) of non-infectious origin without acute organ dysfunction (this code)
• R65.11 Systemic inflammatory response syndrome (SIRS) of non-infectious origin with acute organ dysfunction
• R65.2 Severe sepsis
• R65.20 Severe sepsis without septic shock
• R65.21 Severe sepsis with septic shock