R65.2 Severe sepsis

Non-billable header with 2 child codes.

Applicable to

• Infection with associated acute organ dysfunction
• Sepsis with acute organ dysfunction
• Sepsis with multiple organ dysfunction
• Systemic inflammatory response syndrome due to infectious process with acute organ dysfunction

Code first

• underlying infection, such as:
• infection following a procedure (T81.4-)
• infections following infusion, transfusion and therapeutic injection (T80.2-)
• puerperal sepsis (O85)
• sepsis following complete or unspecified spontaneous abortion (O03.87)
• sepsis following ectopic and molar pregnancy (O08.82)
• sepsis following incomplete spontaneous abortion (O03.37)
• sepsis following (induced) termination of pregnancy (O04.87)
• sepsis NOS (A41.9)

Use additional code

• code to identify specific acute organ dysfunction, such as:
• acute kidney failure (N17.-)
• acute respiratory failure (J96.0-)
• critical illness myopathy (G72.81)
• critical illness polyneuropathy (G62.81)
• disseminated intravascular coagulopathy [DIC] (D65)
• encephalopathy (metabolic) (septic) (G93.41)
• hepatic failure (K72.0-)

Codes under R65.2

• R65.20 Severe sepsis without septic shock
• R65.21 Severe sepsis with septic shock

Code annotations containing back-references to R65.2

Back-references to R65.2

• Code Also: M35.81 Multisystem inflammatory syndrome ("severe sepsis (R65.2-)")
• Use Additional: O03.37 Sepsis following incomplete spontaneous abortion ("code to identify severe sepsis, if applicable (R65.2-)")
• Use Additional: O03.87 Sepsis following complete or unspecified spontaneous abortion ("code to identify severe sepsis, if applicable (R65.2-)")
• Use Additional: O04.87 Sepsis following (induced) termination of pregnancy ("code to identify severe sepsis, if applicable (R65.2-)")
• Use Additional: O07.37 Sepsis following failed attempted termination of pregnancy ("code (R65.2-) to identify severe sepsis, if applicable")
• Use Additional: O08.82 Sepsis following ectopic and molar pregnancy ("code (R65.2-) to identify severe sepsis, if applicable")
• Use Additional: O85 Puerperal sepsis ("code (R65.2-) to identify severe sepsis, if applicable")
• Use Additional: P36 Bacterial sepsis of newborn ("code(s), if applicable, to identify severe sepsis (R65.2-) and associated acute organ dysfunction(s)")
• Type 1 Excludes: R65.1 Systemic inflammatory response syndrome (SIRS) of non-infectious origin ("severe sepsis (R65.2)")
• Use Additional: T80.2 Infections following infusion, transfusion and therapeutic injection ("code (R65.2-) to identify severe sepsis, if applicable")
• Use Additional: T81.4 Infection following a procedure ("code (R65.2-) to identify severe sepsis, if applicable")

Nearby codes

• R65 Symptoms and signs specifically associated with systemic inflammation and infection
• R65.1 Systemic inflammatory response syndrome (SIRS) of non-infectious origin
• R65.10 Systemic inflammatory response syndrome (SIRS) of non-infectious origin without acute organ dysfunction
• R65.11 Systemic inflammatory response syndrome (SIRS) of non-infectious origin with acute organ dysfunction
• R65.2 Severe sepsis (this code)
• R65.20 Severe sepsis without septic shock
• R65.21 Severe sepsis with septic shock