Z15.068 Genetic susceptibility to other malignant neoplasm of digestive system
Billable ICD-10-CM code, FY2026. Exempt from present-on-admission (POA) reporting.
Applicable to
Genetic susceptibility to biliary tract cancer
Genetic susceptibility to gastric cancer
Genetic susceptibility to pancreatic cancer
Genetic susceptibility to small bowel cancer
Applies from Z15 Genetic susceptibility to disease
Includes
confirmed abnormal gene
Excludes1 (never code together)
chromosomal anomalies (Q90-Q99)
Use additional code
code, if applicable, for any associated family history of the disease (Z80-Z84)
Applies from Z15.0 Genetic susceptibility to malignant neoplasm
Code first
, if applicable, any current malignant neoplasm (C00-C75, C81-C96)
Use additional code
code, if applicable, for any personal history of malignant neoplasm (Z85.-)
MS-DRG index
Defines the logic of DRG(s) 951 in MDC 23.
Medicare Code Edits (MCE v43.1 (April 2026))
Unacceptable principal diagnosis: These codes describe a circumstance which influences care but is not a current illness or injury, or capture only an underlying condition, and are unacceptable as principal diagnosis.
Code annotations containing back-references to Z15.068
Back-references to Z15.0
Code Also: Q85.81 PTEN hamartoma tumor syndrome (", if applicable, genetic susceptibility to malignant neoplasm (Z15.0-)")
Use Additional: Z79.81 Long term (current) use of agents affecting estrogen receptors and estrogen levels ("genetic susceptibility to malignant neoplasm (cancer) (Z15.0-)")
Back-references to Z15
Use Additional: Z40.0 Encounter for prophylactic surgery for risk factors related to malignant neoplasms ("code to identify risk factor, such as genetic susceptibility to malignant neoplasm Z15.-")
Diagnosis Index entries for Z15.068
Genetic › susceptibility to disease NEC › malignant neoplasm › biliary tract
Genetic › susceptibility to disease NEC › malignant neoplasm › digestive system NEC
Genetic › susceptibility to disease NEC › malignant neoplasm › gastric
Genetic › susceptibility to disease NEC › malignant neoplasm › pancreas
Nearby codes
Z15.03 Genetic susceptibility to malignant neoplasm of prostate
Z15.04 Genetic susceptibility to malignant neoplasm of endometrium
Z15.05 Genetic susceptibility to malignant neoplasm of fallopian tube(s)
Z15.06 Genetic susceptibility to malignant neoplasm of digestive system
Z15.060 Genetic susceptibility to colorectal cancer
Z15.068 Genetic susceptibility to other malignant neoplasm of digestive system (this code)
Z15.07 Genetic susceptibility to malignant neoplasm of urinary tract
Z15.09 Genetic susceptibility to other malignant neoplasm
Z15.1 Genetic susceptibility to epilepsy and neurodevelopmental disorders