Z15.1 Genetic susceptibility to epilepsy and neurodevelopmental disorders
Billable ICD-10-CM code, FY2026. Exempt from present-on-admission (POA) reporting.
Code also
, if applicable, related disorders such as:
developmental and epileptic encephalopathy (G93.45)
developmental disorder of speech and language (F80.-)
developmental disorders of scholastic skills (F81.-)
epilepsy, by specific type (G40.-)
intellectual disabilities (F70-F79)
other neurodevelopmental disorder (F88)
pervasive developmental disorders (F84.-)
Applies from Z15 Genetic susceptibility to disease
Includes
confirmed abnormal gene
Excludes1 (never code together)
chromosomal anomalies (Q90-Q99)
Use additional code
code, if applicable, for any associated family history of the disease (Z80-Z84)
MS-DRG index
Defines the logic of DRG(s) 951 in MDC 23.
Medicare Code Edits (MCE v43.1 (April 2026))
Unacceptable principal diagnosis: These codes describe a circumstance which influences care but is not a current illness or injury, or capture only an underlying condition, and are unacceptable as principal diagnosis.
Code annotations containing back-references to Z15.1
Back-references to Z15
Use Additional: Z40.0 Encounter for prophylactic surgery for risk factors related to malignant neoplasms ("code to identify risk factor, such as genetic susceptibility to malignant neoplasm Z15.-")
Diagnosis Index entries for Z15.1
Genetic › susceptibility to disease NEC › epilepsy
Genetic › susceptibility to disease NEC › neurodevelopmental disorders
Nearby codes
Z15.06 Genetic susceptibility to malignant neoplasm of digestive system
Z15.060 Genetic susceptibility to colorectal cancer
Z15.068 Genetic susceptibility to other malignant neoplasm of digestive system
Z15.07 Genetic susceptibility to malignant neoplasm of urinary tract
Z15.09 Genetic susceptibility to other malignant neoplasm
Z15.1 Genetic susceptibility to epilepsy and neurodevelopmental disorders (this code)