Z15.89 Genetic susceptibility to other disease

Billable ICD-10-CM code, FY2026. Exempt from present-on-admission (POA) reporting.

Applies from Z15 Genetic susceptibility to disease

Includes

• confirmed abnormal gene

Excludes1 (never code together)

• chromosomal anomalies (Q90-Q99)

Use additional code

• code, if applicable, for any associated family history of the disease (Z80-Z84)

MS-DRG index

Defines the logic of DRG(s) 951 in MDC 23.

Approximate ICD-9-CM (GEMs)

• V84.89 Genetic susceptibility to other disease

Medicare Code Edits (MCE v43.1 (April 2026))

• Unacceptable principal diagnosis: These codes describe a circumstance which influences care but is not a current illness or injury, or capture only an underlying condition, and are unacceptable as principal diagnosis.

Code annotations containing back-references to Z15.89

Back-references to Z15

• Use Additional: Z40.0 Encounter for prophylactic surgery for risk factors related to malignant neoplasms ("code to identify risk factor, such as genetic susceptibility to malignant neoplasm Z15.-")

Diagnosis Index entries for Z15.89

• Genetic › susceptibility to disease NEC
• Susceptibility to disease, genetic

Nearby codes

• Z15.1 Genetic susceptibility to epilepsy and neurodevelopmental disorders
• Z15.2 Genetic susceptibility to obesity
• Z15.3 Genetic susceptibility to kidney disease
• Z15.8 Genetic susceptibility to other disease
• Z15.81 Genetic susceptibility to multiple endocrine neoplasia [MEN]
• Z15.89 Genetic susceptibility to other disease (this code)