Z21 Asymptomatic human immunodeficiency virus [HIV] infection status
Billable ICD-10-CM code, FY2026.
Applicable to
HIV positive NOS
Excludes1 (never code together)
acquired immunodeficiency syndrome (B20)
contact with human immunodeficiency virus [HIV] (Z20.6)
exposure to human immunodeficiency virus [HIV] (Z20.6)
human immunodeficiency virus [HIV] disease (B20)
inconclusive laboratory evidence of human immunodeficiency virus [HIV] (R75)
Code first
Human immunodeficiency virus [HIV] disease complicating pregnancy, childbirth and the puerperium, if applicable (O98.7-)
Applies from Z21 Asymptomatic human immunodeficiency virus [HIV] infection status
Applicable to
HIV positive NOS
Excludes1 (never code together)
acquired immunodeficiency syndrome (B20)
contact with human immunodeficiency virus [HIV] (Z20.6)
exposure to human immunodeficiency virus [HIV] (Z20.6)
human immunodeficiency virus [HIV] disease (B20)
inconclusive laboratory evidence of human immunodeficiency virus [HIV] (R75)
Code first
Human immunodeficiency virus [HIV] disease complicating pregnancy, childbirth and the puerperium, if applicable (O98.7-)
Risk adjustment (HCC)
CMS-HCC V28: HCC 1 — HIV/AIDS
CMS-HCC V22: HCC 1 — HIV/AIDS
RxHCC V08: HCC 1 — HIV/AIDS
ESRD V24: HCC 1
MS-DRG index
Defines the logic of DRG(s) 865-866 in MDC 18.
Approximate ICD-9-CM (GEMs)
V08 Asymptomatic human immunodeficiency virus [HIV] infection status
Medicare Code Edits (MCE v43.1 (April 2026))
Questionable admission: Some diagnoses are not usually sufficient justification for admission to an acute care hospital when reported as principal diagnosis.
Code annotations containing back-references to Z21
Back-references to Z21
Type 1 Excludes: B20 Human immunodeficiency virus [HIV] disease ("asymptomatic human immunodeficiency virus [HIV] infection status (Z21)")
Use Additional: O98.7 Human immunodeficiency virus [HIV] disease complicating pregnancy, childbirth and the puerperium ("Asymptomatic HIV status (Z21)")
Use Additional: O98.7 Human immunodeficiency virus [HIV] disease complicating pregnancy, childbirth and the puerperium ("HIV positive NOS (Z21)")
Type 1 Excludes: R75 Inconclusive laboratory evidence of human immunodeficiency virus [HIV] ("asymptomatic human immunodeficiency virus [HIV] infection status (Z21)")
Type 1 Excludes: Z20.6 Contact with and (suspected) exposure to human immunodeficiency virus [HIV] ("HIV infection status (Z21)")
Type 2 Excludes: Z78 Other specified health status ("asymptomatic human immunodeficiency virus [HIV] infection status (Z21)")
Back-references to Z21
Type 1 Excludes: B20 Human immunodeficiency virus [HIV] disease ("asymptomatic human immunodeficiency virus [HIV] infection status (Z21)")
Use Additional: O98.7 Human immunodeficiency virus [HIV] disease complicating pregnancy, childbirth and the puerperium ("Asymptomatic HIV status (Z21)")
Use Additional: O98.7 Human immunodeficiency virus [HIV] disease complicating pregnancy, childbirth and the puerperium ("HIV positive NOS (Z21)")
Type 1 Excludes: R75 Inconclusive laboratory evidence of human immunodeficiency virus [HIV] ("asymptomatic human immunodeficiency virus [HIV] infection status (Z21)")
Type 1 Excludes: Z20.6 Contact with and (suspected) exposure to human immunodeficiency virus [HIV] ("HIV infection status (Z21)")
Type 2 Excludes: Z78 Other specified health status ("asymptomatic human immunodeficiency virus [HIV] infection status (Z21)")
Diagnosis Index entries for Z21
HIV › positive, seropositive
Human › immunodeficiency virus (HIV) disease (infection) › asymptomatic status
Status (post) › human immunodeficiency virus (HIV) infection, asymptomatic