C94.42 Acute panmyelosis with myelofibrosis, in relapse

Billable ICD-10-CM code, FY2026. Acts as a Complication or Comorbidity (CC) as a secondary diagnosis.

Applies from C94 Other leukemias of specified cell type

Excludes1 (never code together)

• leukemic reticuloendotheliosis (C91.4-)
• myelodysplastic syndromes (D46.-)
• personal history of leukemia (Z85.6)
• plasma cell leukemia (C90.1-)

Applies from C94.4 Acute panmyelosis with myelofibrosis

Applicable to

• Acute myelofibrosis

Excludes1 (never code together)

• myelofibrosis NOS (D75.81)
• secondary myelofibrosis NOS (D75.81)

Risk adjustment (HCC)

• CMS-HCC V28: HCC 17 — Cancer Metastatic to Lung, Liver, Brain, and Other Organs; Acute Myeloid Leukemia Except Promyelocytic
• CMS-HCC V22: HCC 8 — Metastatic Cancer and Acute Leukemia
• RxHCC V08: HCC 19 — Leukemias and Other Hematologic Cancers
• ESRD V24: HCC 8

MS-DRG index

Defines the logic of DRG(s) 820-822 in MDC 17.

Approximate ICD-9-CM (GEMs)

• 238.79 Other lymphatic and hematopoietic tissues (approximate)

Code annotations containing back-references to C94.42

Back-references to C94.4

• Type 1 Excludes: D47.4 Osteomyelofibrosis ("acute myelofibrosis (C94.4-)")
• Type 1 Excludes: D75.81 Myelofibrosis ("acute myelofibrosis (C94.4-)")

Back-references to C94

• Type 1 Excludes: C76 Malignant neoplasm of other and ill-defined sites ("malignant neoplasm of lymphoid, hematopoietic and related tissue (C81-C96)")
• Type 1 Excludes: D72.8 Other specified disorders of white blood cells ("leukemia (C91-C95)")
• Type 1 Excludes: D72.825 Bandemia ("leukemia (C91.-, C92.-, C93.-, C94.-, C95.-)")
• Code First: M36.1 Arthropathy in neoplastic disease ("leukemia (C91-C95)")
• Code First: N16 Renal tubulo-interstitial disorders in diseases classified elsewhere ("leukemia (C91-C95)")
• Code First: R50.81 Fever presenting with conditions classified elsewhere ("leukemia (C91-C95)")
• Type 1 Excludes: T66 Radiation sickness, unspecified ("leukemia (C91-C95)")
• Code First: Z15.0 Genetic susceptibility to malignant neoplasm (", if applicable, any current malignant neoplasm (C00-C75, C81-C96)")

Nearby codes

• C94.31 Mast cell leukemia, in remission
• C94.32 Mast cell leukemia, in relapse
• C94.4 Acute panmyelosis with myelofibrosis
• C94.40 Acute panmyelosis with myelofibrosis not having achieved remission
• C94.41 Acute panmyelosis with myelofibrosis, in remission
• C94.42 Acute panmyelosis with myelofibrosis, in relapse (this code)
• C94.6 Myelodysplastic disease, not elsewhere classified
• C94.8 Other specified leukemias
• C94.80 Other specified leukemias not having achieved remission
• C94.81 Other specified leukemias, in remission
• C94.82 Other specified leukemias, in relapse