D75.81 Myelofibrosis

Billable ICD-10-CM code, FY2026. Acts as a Complication or Comorbidity (CC) as a secondary diagnosis.

Applicable to

• Myelofibrosis NOS
• Secondary myelofibrosis NOS

Excludes1 (never code together)

• acute myelofibrosis (C94.4-)
• idiopathic myelofibrosis (D47.1)
• leukoerythroblastic anemia (D61.82)
• myelofibrosis with myeloid metaplasia (D47.4)
• myelophthisic anemia (D61.82)
• myelophthisis (D61.82)
• primary myelofibrosis (D47.1)

Code first

• the underlying disorder, such as:
• malignant neoplasm of breast (C50.-)

Use additional code

• code, if applicable, for associated therapy-related myelodysplastic syndrome (D46.-)
• code for adverse effect, if applicable, to identify drug (T45.1X5)

Applies from D75 Other and unspecified diseases of blood and blood-forming organs

Excludes2 (not included here)

• acute lymphadenitis (L04.-)
• chronic lymphadenitis (I88.1)
• enlarged lymph nodes (R59.-)
• hypergammaglobulinemia NOS (D89.2)
• lymphadenitis NOS (I88.9)
• mesenteric lymphadenitis (acute) (chronic) (I88.0)

Risk adjustment (HCC)

• CMS-HCC V28: HCC 19 — Myelodysplastic Syndromes, Multiple Myeloma, and Other Cancers
• CMS-HCC V22: HCC 46 — Severe Hematological Disorders
• RxHCC V08: HCC 16 — Multiple Myeloma and Other Hematologic Cancers
• ESRD V24: HCC 46

MS-DRG index

Defines the logic of DRG(s) 820-822 in MDC 17.

Approximate ICD-9-CM (GEMs)

• 289.83 Myelofibrosis

Medicare Code Edits (MCE v43.1 (April 2026))

• Manifestation codes as principal diagnosis: Manifestation codes describe the manifestation of an underlying disease, not the disease itself, and are not allowed as principal diagnosis.

Code annotations containing back-references to D75.81

Back-references to D75.81

• Type 1 Excludes: C94.4 Acute panmyelosis with myelofibrosis ("myelofibrosis NOS (D75.81)")
• Type 1 Excludes: C94.4 Acute panmyelosis with myelofibrosis ("secondary myelofibrosis NOS (D75.81)")
• Type 1 Excludes: D47.1 Chronic myeloproliferative disease ("myelofibrosis NOS (D75.81)")
• Type 1 Excludes: D47.1 Chronic myeloproliferative disease ("secondary myelofibrosis NOS (D75.81)")
• Type 1 Excludes: D61.82 Myelophthisis ("myelofibrosis NOS (D75.81)")
• Type 1 Excludes: D61.82 Myelophthisis ("secondary myelofibrosis (D75.81)")
• Type 1 Excludes: M85.8 Other specified disorders of bone density and structure ("osteosclerosis myelofibrosis (D75.81)")

Diagnosis Index entries for D75.81

• Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › myelofibrosis
• Myelofibrosis
• Myelofibrosis › secondary
• Osteosclerosis › myelofibrosis

Nearby codes

• D75 Other and unspecified diseases of blood and blood-forming organs
• D75.0 Familial erythrocytosis
• D75.1 Secondary polycythemia
• D75.8 Other specified diseases of blood and blood-forming organs
• D75.81 Myelofibrosis (this code)
• D75.82 Heparin induced thrombocytopenia (HIT)
• D75.821 Non-immune heparin-induced thrombocytopenia
• D75.822 Immune-mediated heparin-induced thrombocytopenia
• D75.828 Other heparin-induced thrombocytopenia syndrome
• D75.829 Heparin-induced thrombocytopenia, unspecified