D55.1 Anemia due to other disorders of glutathione metabolism

Billable ICD-10-CM code, FY2026.

Applicable to

• Anemia (due to) enzyme deficiencies, except G6PD, related to the hexose monophosphate [HMP] shunt pathway
• Anemia (due to) hemolytic nonspherocytic (hereditary), type I

Applies from D55 Anemia due to enzyme disorders

Excludes1 (never code together)

• drug-induced enzyme deficiency anemia (D59.2)

Risk adjustment (HCC)

• CMS-HCC V22: HCC 48 — Coagulation Defects and Other Specified Hematological Disorders
• ESRD V24: HCC 48

MS-DRG index

Defines the logic of DRG(s) 811-812 in MDC 16.

Approximate ICD-9-CM (GEMs)

• 282.2 Anemias due to disorders of glutathione metabolism (approximate)

Code annotations containing back-references to D55.1

Back-references to D55

• Type 1 Excludes: E74.4 Disorders of pyruvate metabolism and gluconeogenesis ("disorders of pyruvate metabolism and gluconeogenesis with anemia (D55.-)")
• Code First: M90.5 Osteonecrosis in diseases classified elsewhere ("hemoglobinopathy (D50-D64)")
• Type 1 Excludes: R71 Abnormality of red blood cells ("anemias (D50-D64)")

Diagnosis Index entries for D55.1

• Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › with (due to) (in) › disorder of › pentose phosphate pathway
• Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › deficiency › 6 phosphogluconate dehydrogenase
• Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › deficiency › 6-PGD
• Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › deficiency › enzyme › related to hexose monophosphate (HMP) shunt pathway NEC
• Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › deficiency › erythrocytic glutathione
• Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › deficiency › G SH
• Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › deficiency › GGS-R
• Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › deficiency › glutathione reductase
• Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › due to (in) (with) › disorder of › glutathione metabolism
• Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › erythrocytic glutathione deficiency
• Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › glutathione-reductase deficiency
• Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › hemolytic › nonspherocytic › congenital or hereditary NEC › type › I
• Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › hemolytic › nonspherocytic › type › I
• Disorder (of) › pentose phosphate pathway with anemia

Nearby codes

• D55 Anemia due to enzyme disorders
• D55.0 Anemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiency
• D55.1 Anemia due to other disorders of glutathione metabolism (this code)
• D55.2 Anemia due to disorders of glycolytic enzymes
• D55.21 Anemia due to pyruvate kinase deficiency
• D55.29 Anemia due to other disorders of glycolytic enzymes
• D55.3 Anemia due to disorders of nucleotide metabolism
• D55.8 Other anemias due to enzyme disorders