D55.8 Other anemias due to enzyme disorders

Billable ICD-10-CM code, FY2026.

Applies from D55 Anemia due to enzyme disorders

Excludes1 (never code together)

• drug-induced enzyme deficiency anemia (D59.2)

Risk adjustment (HCC)

• CMS-HCC V22: HCC 48 — Coagulation Defects and Other Specified Hematological Disorders
• ESRD V24: HCC 48

MS-DRG index

Defines the logic of DRG(s) 811-812 in MDC 16.

Approximate ICD-9-CM (GEMs)

• 282.3 Other hemolytic anemias due to enzyme deficiency (approximate)

Code annotations containing back-references to D55.8

Back-references to D55

• Type 1 Excludes: E74.4 Disorders of pyruvate metabolism and gluconeogenesis ("disorders of pyruvate metabolism and gluconeogenesis with anemia (D55.-)")
• Code First: M90.5 Osteonecrosis in diseases classified elsewhere ("hemoglobinopathy (D50-D64)")
• Type 1 Excludes: R71 Abnormality of red blood cells ("anemias (D50-D64)")

Diagnosis Index entries for D55.8

• Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › deficiency › enzyme › specified type NEC
• Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › hemolytic › acute › due to enzyme deficiency specified type NEC
• Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › hemolytic › hereditary › due to enzyme disorder › specified type NEC
• Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › hemolytic › nonspherocytic › congenital or hereditary NEC

Nearby codes

• D55.1 Anemia due to other disorders of glutathione metabolism
• D55.2 Anemia due to disorders of glycolytic enzymes
• D55.21 Anemia due to pyruvate kinase deficiency
• D55.29 Anemia due to other disorders of glycolytic enzymes
• D55.3 Anemia due to disorders of nucleotide metabolism
• D55.8 Other anemias due to enzyme disorders (this code)
• D55.9 Anemia due to enzyme disorder, unspecified