D55.29 Anemia due to other disorders of glycolytic enzymes

Billable ICD-10-CM code, FY2026.

Applicable to

• Hexokinase deficiency anemia
• Triose-phosphate isomerase deficiency anemia

Applies from D55 Anemia due to enzyme disorders

Excludes1 (never code together)

• drug-induced enzyme deficiency anemia (D59.2)

Applies from D55.2 Anemia due to disorders of glycolytic enzymes

Excludes1 (never code together)

• disorders of glycolysis not associated with anemia (E74.81-)

Risk adjustment (HCC)

• CMS-HCC V22: HCC 48 — Coagulation Defects and Other Specified Hematological Disorders
• ESRD V24: HCC 48

MS-DRG index

Defines the logic of DRG(s) 811-812 in MDC 16.

Code annotations containing back-references to D55.29

Back-references to D55

• Type 1 Excludes: E74.4 Disorders of pyruvate metabolism and gluconeogenesis ("disorders of pyruvate metabolism and gluconeogenesis with anemia (D55.-)")
• Code First: M90.5 Osteonecrosis in diseases classified elsewhere ("hemoglobinopathy (D50-D64)")
• Type 1 Excludes: R71 Abnormality of red blood cells ("anemias (D50-D64)")

Diagnosis Index entries for D55.29

• Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › with (due to) (in) › disorder of › anaerobic glycolysis
• Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › deficiency › 2, 3 diphosphoglycurate mutase
• Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › deficiency › 2, 3 PG
• Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › deficiency › enzyme › glycolytic
• Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › deficiency › glyceraldehyde phosphate dehydrogenase
• Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › deficiency › hexokinase
• Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › deficiency › phosphofructo-aldolase
• Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › deficiency › phosphoglycerate kinase
• Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › deficiency › triose-phosphate isomerase
• Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › hemolytic › nonspherocytic › congenital or hereditary NEC › type › II
• Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › hemolytic › nonspherocytic › type › II
• Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › hexokinase deficiency
• Disorder (of) › anaerobic glycolysis with anemia

Nearby codes

• D55 Anemia due to enzyme disorders
• D55.0 Anemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiency
• D55.1 Anemia due to other disorders of glutathione metabolism
• D55.2 Anemia due to disorders of glycolytic enzymes
• D55.21 Anemia due to pyruvate kinase deficiency
• D55.29 Anemia due to other disorders of glycolytic enzymes (this code)
• D55.3 Anemia due to disorders of nucleotide metabolism
• D55.8 Other anemias due to enzyme disorders
• D55.9 Anemia due to enzyme disorder, unspecified