D57.1 Sickle-cell disease without crisis

Billable ICD-10-CM code, FY2026.

Applicable to

• Hb-SS disease without crisis
• Sickle-cell anemia NOS
• Sickle-cell disease NOS
• Sickle-cell disorder NOS

Applies from D57 Sickle-cell disorders

Excludes1 (never code together)

• other hemoglobinopathies (D58.-)

Use additional code

• code for any associated fever (R50.81)

Risk adjustment (HCC)

• CMS-HCC V28: HCC 107 — Sickle Cell Anemia (Hb-SS) and Thalassemia Beta Zero
• CMS-HCC V22: HCC 46 — Severe Hematological Disorders
• RxHCC V08: HCC 95 — Sickle Cell Anemia
• ESRD V24: HCC 46

MS-DRG index

Defines the logic of DRG(s) 811-812 in MDC 16.

Approximate ICD-9-CM (GEMs)

• 282.60 Sickle-cell disease, unspecified (approximate)
• 282.61 Hb-SS disease without crisis (approximate)

Code annotations containing back-references to D57.1

Back-references to D57.1

• Code First: N08 Glomerular disorders in diseases classified elsewhere ("sickle-cell disease (D57.0-D57.8)")

Back-references to D57

• Type 1 Excludes: D56.8 Other thalassemias ("sickle-cell anemia (D57.-)")
• Code First: H36 Retinal disorders in diseases classified elsewhere ("sickle-cell disorders (D57.-)")
• Code First: M14.8 Arthropathies in other specified diseases classified elsewhere ("sickle-cell disorders (D57.-)")
• Code First: M90.5 Osteonecrosis in diseases classified elsewhere ("hemoglobinopathy (D50-D64)")
• Code First: R50.81 Fever presenting with conditions classified elsewhere ("sickle-cell disease (D57.-)")
• Type 1 Excludes: R71 Abnormality of red blood cells ("anemias (D50-D64)")
• Code Also: Z71.87 Encounter for pediatric-to-adult transition counseling ("sickle-cell disorder (D57.-)")

Diagnosis Index entries for D57.1

• Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › Herrick's
• Disease, diseased › hemoglobin or Hb › S or SS
• Disease, diseased › sickle-cell
• Hemoglobinopathy (mixed) › sickle-cell

Nearby codes

• D57.01 Hb-SS disease with acute chest syndrome
• D57.02 Hb-SS disease with splenic sequestration
• D57.03 Hb-SS disease with cerebral vascular involvement
• D57.04 Hb-SS disease with dactylitis
• D57.09 Hb-SS disease with crisis with other specified complication
• D57.1 Sickle-cell disease without crisis (this code)
• D57.2 Sickle-cell/Hb-C disease
• D57.20 Sickle-cell/Hb-C disease without crisis
• D57.21 Sickle-cell/Hb-C disease with crisis
• D57.211 Sickle-cell/Hb-C disease with acute chest syndrome
• D57.212 Sickle-cell/Hb-C disease with splenic sequestration