D57.451 Sickle-cell thalassemia beta plus with acute chest syndrome

Billable ICD-10-CM code, FY2026. Acts as a Major Complication or Comorbidity (MCC) as a secondary diagnosis.

Applicable to

• HbS-beta plus with acute chest syndrome
• Sickle-cell beta plus with acute chest syndrome

Applies from D57 Sickle-cell disorders

Excludes1 (never code together)

• other hemoglobinopathies (D58.-)

Use additional code

• code for any associated fever (R50.81)

Applies from D57.4 Sickle-cell thalassemia

Applicable to

• Sickle-cell beta thalassemia
• Thalassemia Hb-S disease

Applies from D57.45 Sickle-cell thalassemia beta plus with crisis

Applicable to

• HbS-beta plus with crisis
• Sickle-cell beta plus with crisis

Risk adjustment (HCC)

• CMS-HCC V28: HCC 108 — Sickle Cell Disorders, Except Sickle Cell Anemia (Hb-SS) and Thalassemia Beta Zero; Beta Thalassemia Major
• CMS-HCC V22: HCC 46 — Severe Hematological Disorders
• ESRD V24: HCC 46

MS-DRG index

Defines the logic of DRG(s) 791 in MDC 15.

Code annotations containing back-references to D57.451

Back-references to D57.4

• Type 1 Excludes: D56 Thalassemia ("sickle-cell thalassemia (D57.4-)")
• Type 1 Excludes: D56.1 Beta thalassemia ("sickle-cell beta thalassemia (D57.4-)")
• Type 1 Excludes: D56.5 Hemoglobin E-beta thalassemia ("sickle-cell beta thalassemia (D57.4-)")
• Type 1 Excludes: D56.8 Other thalassemias ("sickle-cell thalassemia (D57.4-)")
• Code First: N08 Glomerular disorders in diseases classified elsewhere ("sickle-cell disease (D57.0-D57.8)")

Back-references to D57

• Type 1 Excludes: D56.8 Other thalassemias ("sickle-cell anemia (D57.-)")
• Code First: H36 Retinal disorders in diseases classified elsewhere ("sickle-cell disorders (D57.-)")
• Code First: M14.8 Arthropathies in other specified diseases classified elsewhere ("sickle-cell disorders (D57.-)")
• Code First: M90.5 Osteonecrosis in diseases classified elsewhere ("hemoglobinopathy (D50-D64)")
• Code First: R50.81 Fever presenting with conditions classified elsewhere ("sickle-cell disease (D57.-)")
• Type 1 Excludes: R71 Abnormality of red blood cells ("anemias (D50-D64)")
• Code Also: Z71.87 Encounter for pediatric-to-adult transition counseling ("sickle-cell disorder (D57.-)")

Diagnosis Index entries for D57.451

• Disease, diseased › hemoglobin or Hb › S or SS › beta plus › with › acute chest syndrome
• Disease, diseased › sickle-cell › thalassemia › beta plus › with › acute chest syndrome

Nearby codes

• D57.434 Sickle-cell thalassemia beta zero with dactylitis
• D57.438 Sickle-cell thalassemia beta zero with crisis with other specified complication
• D57.439 Sickle-cell thalassemia beta zero with crisis, unspecified
• D57.44 Sickle-cell thalassemia beta plus without crisis
• D57.45 Sickle-cell thalassemia beta plus with crisis
• D57.451 Sickle-cell thalassemia beta plus with acute chest syndrome (this code)
• D57.452 Sickle-cell thalassemia beta plus with splenic sequestration
• D57.453 Sickle-cell thalassemia beta plus with cerebral vascular involvement
• D57.454 Sickle-cell thalassemia beta plus with dactylitis
• D57.458 Sickle-cell thalassemia beta plus with crisis with other specified complication
• D57.459 Sickle-cell thalassemia beta plus with crisis, unspecified