D56.1 Beta thalassemia

Billable ICD-10-CM code, FY2026.

Applicable to

• Beta thalassemia major
• Cooley's anemia
• Homozygous beta thalassemia
• Severe beta thalassemia
• Thalassemia intermedia
• Thalassemia major

Excludes1 (never code together)

• beta thalassemia minor (D56.3)
• beta thalassemia trait (D56.3)
• delta-beta thalassemia (D56.2)
• hemoglobin E-beta thalassemia (D56.5)
• sickle-cell beta thalassemia (D57.4-)

Applies from D56 Thalassemia

Excludes1 (never code together)

• sickle-cell thalassemia (D57.4-)

Risk adjustment (HCC)

• CMS-HCC V28: HCC 108 — Sickle Cell Disorders, Except Sickle Cell Anemia (Hb-SS) and Thalassemia Beta Zero; Beta Thalassemia Major
• CMS-HCC V22: HCC 48 — Coagulation Defects and Other Specified Hematological Disorders
• ESRD V24: HCC 48

MS-DRG index

Defines the logic of DRG(s) 791 in MDC 15.

Approximate ICD-9-CM (GEMs)

• 282.44 Beta thalassemia

Code annotations containing back-references to D56.1

Back-references to D56.1

• Type 1 Excludes: D56.3 Thalassemia minor ("beta thalassemia (D56.1)")
• Type 1 Excludes: D56.5 Hemoglobin E-beta thalassemia ("beta thalassemia (D56.1)")

Back-references to D56

• Code First: M36.3 Arthropathy in other blood disorders ("thalassemia (D56.-)")
• Code First: M90.5 Osteonecrosis in diseases classified elsewhere ("hemoglobinopathy (D50-D64)")
• Type 1 Excludes: R71 Abnormality of red blood cells ("anemias (D50-D64)")

Diagnosis Index entries for D56.1

• Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › Cooley's (erythroblastic)
• Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › erythroblastic › familial
• Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › erythroblastic › of childhood
• Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › familial erythroblastic
• Cooley's anemia
• Thalassemia (anemia) (disease) › beta (severe)
• Thalassemia (anemia) (disease) › beta (severe) › homozygous
• Thalassemia (anemia) (disease) › beta (severe) › major
• Thalassemia (anemia) (disease) › intermedia
• Thalassemia (anemia) (disease) › major

Nearby codes

• D56 Thalassemia
• D56.0 Alpha thalassemia
• D56.1 Beta thalassemia (this code)
• D56.2 Delta-beta thalassemia
• D56.3 Thalassemia minor
• D56.4 Hereditary persistence of fetal hemoglobin [HPFH]
• D56.5 Hemoglobin E-beta thalassemia
• D56.8 Other thalassemias