D56.4 Hereditary persistence of fetal hemoglobin [HPFH]

Billable ICD-10-CM code, FY2026.

Applies from D56 Thalassemia

Excludes1 (never code together)

• sickle-cell thalassemia (D57.4-)

Risk adjustment (HCC)

• CMS-HCC V22: HCC 48 — Coagulation Defects and Other Specified Hematological Disorders
• ESRD V24: HCC 48

MS-DRG index

Defines the logic of DRG(s) 811-812 in MDC 16.

Approximate ICD-9-CM (GEMs)

• 282.7 Other hemoglobinopathies (approximate)

Code annotations containing back-references to D56.4

Back-references to D56.4

• Type 1 Excludes: D58.2 Other hemoglobinopathies ("hereditary persistence of fetal hemoglobin [HPFH] (D56.4)")

Back-references to D56

• Code First: M36.3 Arthropathy in other blood disorders ("thalassemia (D56.-)")
• Code First: M90.5 Osteonecrosis in diseases classified elsewhere ("hemoglobinopathy (D50-D64)")
• Type 1 Excludes: R71 Abnormality of red blood cells ("anemias (D50-D64)")

Diagnosis Index entries for D56.4

• Hemoglobin › fetal, hereditary persistence (HPFH)
• Persistence, persistent (congenital) › fetal › hemoglobin, hereditary (HPFH)
• Persistence, persistent (congenital) › hemoglobin, fetal (hereditary) (HPFH)

Nearby codes

• D56 Thalassemia
• D56.0 Alpha thalassemia
• D56.1 Beta thalassemia
• D56.2 Delta-beta thalassemia
• D56.3 Thalassemia minor
• D56.4 Hereditary persistence of fetal hemoglobin [HPFH] (this code)
• D56.5 Hemoglobin E-beta thalassemia
• D56.8 Other thalassemias
• D56.9 Thalassemia, unspecified