D68.1 Hereditary factor XI deficiency

Billable ICD-10-CM code, FY2026. Acts as a Complication or Comorbidity (CC) as a secondary diagnosis.

Applicable to

• Hemophilia C
• Plasma thromboplastin antecedent [PTA] deficiency
• Rosenthal's disease

Applies from D68 Other coagulation defects

Excludes1 (never code together)

• abnormal coagulation profile NOS (R79.1)

Excludes2 (not included here)

• coagulation defects complicating abortion or ectopic or molar pregnancy (O00-O07, O08.1)
• coagulation defects complicating pregnancy, childbirth and the puerperium (O45.0, O46.0, O67.0, O72.3)

Risk adjustment (HCC)

• CMS-HCC V28: HCC 112 — Immune Thrombocytopenia and Specified Coagulation Defects and Hemorrhagic Conditions
• CMS-HCC V22: HCC 48 — Coagulation Defects and Other Specified Hematological Disorders
• ESRD V24: HCC 48

MS-DRG index

Defines the logic of DRG(s) 813 in MDC 16.

Approximate ICD-9-CM (GEMs)

• 286.2 Congenital factor XI deficiency

Code annotations containing back-references to D68.1

Back-references to D68.1

• Code First: M36.2 Hemophilic arthropathy ("hemophilia C (D68.1)")

Back-references to D68

• Type 1 Excludes: R79.1 Abnormal coagulation profile ("coagulation defects (D68.-)")

Diagnosis Index entries for D68.1

• Deficiency, deficient › anti-hemophilic › factor (A) › C
• Deficiency, deficient › factor › XI (congenital) (hereditary)
• Deficiency, deficient › plasma thromboplastin › antecedent (PTA)
• Deficiency, deficient › PTA (plasma thromboplastin antecedent)
• Disease, diseased › Rosenthal's (factor XI deficiency)
• Hemophilia (classical) (familial) (hereditary) › C
• Rosenthal's disease or syndrome

Nearby codes

• D68.023 Von Willebrand disease, type 2N
• D68.029 Von Willebrand disease, type 2, unspecified
• D68.03 Von Willebrand disease, type 3
• D68.04 Acquired von Willebrand disease
• D68.09 Other von Willebrand disease
• D68.1 Hereditary factor XI deficiency (this code)
• D68.2 Hereditary deficiency of other clotting factors
• D68.3 Hemorrhagic disorder due to circulating anticoagulants
• D68.31 Hemorrhagic disorder due to intrinsic circulating anticoagulants, antibodies, or inhibitors
• D68.311 Acquired hemophilia
• D68.312 Antiphospholipid antibody with hemorrhagic disorder