D68.61 Antiphospholipid syndrome

Billable ICD-10-CM code, FY2026. Acts as a Complication or Comorbidity (CC) as a secondary diagnosis.

Applicable to

• Anticardiolipin syndrome
• Antiphospholipid antibody syndrome

Excludes1 (never code together)

• anti-phospholipid antibody, finding without diagnosis (R76.0)

Excludes2 (not included here)

• anti-phospholipid antibody with hemorrhagic disorder (D68.312)
• lupus anticoagulant syndrome (D68.62)

Applies from D68 Other coagulation defects

Excludes1 (never code together)

• abnormal coagulation profile NOS (R79.1)

Excludes2 (not included here)

• coagulation defects complicating abortion or ectopic or molar pregnancy (O00-O07, O08.1)
• coagulation defects complicating pregnancy, childbirth and the puerperium (O45.0, O46.0, O67.0, O72.3)

Applies from D68.6 Other thrombophilia

Applicable to

• Other hypercoagulable states

Excludes1 (never code together)

• diffuse or disseminated intravascular coagulation [DIC] (D65)
• heparin induced thrombocytopenia (HIT) (D75.82-)
• hyperhomocysteinemia (E72.11)

Risk adjustment (HCC)

• CMS-HCC V22: HCC 48 — Coagulation Defects and Other Specified Hematological Disorders
• ESRD V24: HCC 48

MS-DRG index

Defines the logic of DRG(s) 814-816 in MDC 16.

Approximate ICD-9-CM (GEMs)

• 289.81 Primary hypercoagulable state (approximate)

Code annotations containing back-references to D68.61

Back-references to D68.61

• Type 2 Excludes: D68.312 Antiphospholipid antibody with hemorrhagic disorder ("antiphospholipid antibody syndrome (D68.61)")
• Type 2 Excludes: D68.312 Antiphospholipid antibody with hemorrhagic disorder ("antiphospholipid antibody with hypercoagulable state (D68.61)")
• Type 1 Excludes: D68.5 Primary thrombophilia ("antiphospholipid syndrome (D68.61)")
• Type 2 Excludes: D68.62 Lupus anticoagulant syndrome ("anticardiolipin syndrome (D68.61)")
• Type 2 Excludes: D68.62 Lupus anticoagulant syndrome ("antiphospholipid syndrome (D68.61)")

Back-references to D68

• Type 1 Excludes: R79.1 Abnormal coagulation profile ("coagulation defects (D68.-)")

Diagnosis Index entries for D68.61

• Antibody › anticardiolipin › with › hypercoagulable state
• Antibody › antiphosphatidylglycerol › with › hypercoagulable state
• Antibody › antiphosphatidylinositol › with › hypercoagulable state
• Antibody › antiphosphatidylserine › with › hypercoagulable state
• Antibody › antiphospholipid › with › hypercoagulable state
• Anticardiolipin syndrome
• Antiphospholipid › antibody › syndrome
• Syndrome › anticardiolipin (-antibody)
• Syndrome › antiphospholipid (-antibody)

Nearby codes

• D68.5 Primary thrombophilia
• D68.51 Activated protein C resistance
• D68.52 Prothrombin gene mutation
• D68.59 Other primary thrombophilia
• D68.6 Other thrombophilia
• D68.61 Antiphospholipid syndrome (this code)
• D68.62 Lupus anticoagulant syndrome
• D68.69 Other thrombophilia
• D68.8 Other specified coagulation defects
• D68.9 Coagulation defect, unspecified