D89.3 Immune reconstitution syndrome

Billable ICD-10-CM code, FY2026.

Applicable to

• Immune reconstitution inflammatory syndrome [IRIS]

Use additional code

• code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)

Applies from D89 Other disorders involving the immune mechanism, not elsewhere classified

Excludes1 (never code together)

• hyperglobulinemia NOS (R77.1)
• monoclonal gammopathy (of undetermined significance) (D47.2)

Excludes2 (not included here)

• transplant failure and rejection (T86.-)

Risk adjustment (HCC)

• CMS-HCC V22: HCC 47 — Disorders of Immunity
• RxHCC V08: HCC 99 — Immune Disorders
• ESRD V24: HCC 47

MS-DRG index

Defines the logic of DRG(s) 814-816 in MDC 16.

Approximate ICD-9-CM (GEMs)

• 279.8 Other specified disorders involving the immune mechanism (approximate)

Code annotations containing back-references to D89.3

Back-references to D89

• Type 1 Excludes: D72 Other disorders of white blood cells ("immunity disorders (D80-D89)")

Diagnosis Index entries for D89.3

• Immune reconstitution (inflammatory) syndrome [IRIS]
• Syndrome › immune reconstitution
• Syndrome › immune reconstitution inflammatory [IRIS]

Nearby codes

• D89 Other disorders involving the immune mechanism, not elsewhere classified
• D89.0 Polyclonal hypergammaglobulinemia
• D89.1 Cryoglobulinemia
• D89.2 Hypergammaglobulinemia, unspecified
• D89.3 Immune reconstitution syndrome (this code)
• D89.4 Mast cell activation syndrome and related disorders
• D89.40 Mast cell activation, unspecified
• D89.41 Monoclonal mast cell activation syndrome
• D89.42 Idiopathic mast cell activation syndrome
• D89.43 Secondary mast cell activation