D89.1 Cryoglobulinemia

Billable ICD-10-CM code, FY2026.

Applicable to

• Cryoglobulinemic purpura
• Cryoglobulinemic vasculitis
• Essential cryoglobulinemia
• Idiopathic cryoglobulinemia
• Mixed cryoglobulinemia
• Primary cryoglobulinemia
• Secondary cryoglobulinemia

Applies from D89 Other disorders involving the immune mechanism, not elsewhere classified

Excludes1 (never code together)

• hyperglobulinemia NOS (R77.1)
• monoclonal gammopathy (of undetermined significance) (D47.2)

Excludes2 (not included here)

• transplant failure and rejection (T86.-)

Risk adjustment (HCC)

• CMS-HCC V22: HCC 23 — Other Significant Endocrine and Metabolic Disorders
• RxHCC V08: HCC 99 — Immune Disorders
• ESRD V24: HCC 23

MS-DRG index

Defines the logic of DRG(s) 820-822 in MDC 17.

Approximate ICD-9-CM (GEMs)

• 273.2 Other paraproteinemias

Code annotations containing back-references to D89.1

Back-references to D89.1

• Type 1 Excludes: D69 Purpura and other hemorrhagic conditions ("cryoglobulinemic purpura (D89.1)")
• Code First: J99 Respiratory disorders in diseases classified elsewhere ("cryoglobulinemia (D89.1)")
• Code First: N08 Glomerular disorders in diseases classified elsewhere ("cryoglobulinemia (D89.1)")
• Code First: N16 Renal tubulo-interstitial disorders in diseases classified elsewhere ("cryoglobulinemia (D89.1)")

Back-references to D89

• Type 1 Excludes: D72 Other disorders of white blood cells ("immunity disorders (D80-D89)")

Diagnosis Index entries for D89.1

• Cryoglobulinemia (essential) (idiopathic) (mixed) (primary) (purpura) (secondary) (vasculitis)
• Cryoglobulinemia (essential) (idiopathic) (mixed) (primary) (purpura) (secondary) (vasculitis) › with lung involvement
• Disorder (of) › glomerular (in) › cryoglobulinemia
• Disorder (of) › tubulo-interstitial (in) › mixed cryoglobulinemia
• Glomerulonephritis › in (due to) › cryoglobulinemia
• Nephritis, nephritic (albuminuric) (azotemic) (congenital) (disseminated) (epithelial) (familial) (focal) (granulomatous) (hemorrhagic) (infantile) (nonsuppurative, excretory) (uremic) › tubulo-interstitial (in) › due to › cryoglobulinemia
• Purpura › cryoglobulinemic
• Pyelonephritis › in (due to) › cryoglobulinemia (mixed)
• Vasculitis › cryoglobulinemic

Nearby codes

• D89 Other disorders involving the immune mechanism, not elsewhere classified
• D89.0 Polyclonal hypergammaglobulinemia
• D89.1 Cryoglobulinemia (this code)
• D89.2 Hypergammaglobulinemia, unspecified
• D89.3 Immune reconstitution syndrome
• D89.4 Mast cell activation syndrome and related disorders
• D89.40 Mast cell activation, unspecified
• D89.41 Monoclonal mast cell activation syndrome