E08.641 Diabetes mellitus due to underlying condition with hypoglycemia with coma

Billable ICD-10-CM code, FY2026. Acts as a Major Complication or Comorbidity (MCC) as a secondary diagnosis.

Applies from E08 Diabetes mellitus due to underlying condition

Excludes1 (never code together)

• drug or chemical induced diabetes mellitus (E09.-)
• gestational diabetes (O24.4-)
• neonatal diabetes mellitus (P70.2)
• postpancreatectomy diabetes mellitus (E13.-)
• postprocedural diabetes mellitus (E13.-)
• secondary diabetes mellitus NEC (E13.-)
• type 1 diabetes mellitus (E10.-)
• type 2 diabetes mellitus (E11.-)

Code first

• the underlying condition, such as:
• congenital rubella (P35.0)
• Cushing's syndrome (E24.-)
• cystic fibrosis (E84.-)
• malignant neoplasm (C00-C96)
• malnutrition (E40-E46)
• pancreatitis and other diseases of the pancreas (K85-K86.-)

Use additional code

• code to identify control using:
• injectable non-insulin antidiabetic drugs (Z79.85)
• insulin (Z79.4)
• oral antidiabetic drugs (Z79.84)
• oral hypoglycemic drugs (Z79.84)

Applies from E08.64 Diabetes mellitus due to underlying condition with hypoglycemia

Use additional code

• code for hypoglycemia level, if applicable (E16.A-)

Risk adjustment (HCC)

• CMS-HCC V28: HCC 36 — Diabetes with Severe Acute Complications
• CMS-HCC V22: HCC 17 — Diabetes with Acute Complications
• RxHCC V08: HCC 30 — Diabetes with Complications
• ESRD V24: HCC 17

MS-DRG index

Defines the logic of DRG(s) 008 in MDC PRE.

Approximate ICD-9-CM (GEMs)

• 249.30 Secondary diabetes mellitus with other coma, not stated as uncontrolled, or unspecified (approximate)

Medicare Code Edits (MCE v43.1 (April 2026))

• Manifestation codes as principal diagnosis: Manifestation codes describe the manifestation of an underlying disease, not the disease itself, and are not allowed as principal diagnosis.

Code annotations containing back-references to E08.641

Back-references to E08

• Code First: D84.81 Immunodeficiency due to conditions classified elsewhere ("diabetes mellitus (E08-E13)")
• Type 1 Excludes: E09 Drug or chemical induced diabetes mellitus ("diabetes mellitus due to underlying condition (E08.-)")
• Type 1 Excludes: E10 Type 1 diabetes mellitus ("diabetes mellitus due to underlying condition (E08.-)")
• Type 1 Excludes: E11 Type 2 diabetes mellitus ("diabetes mellitus due to underlying condition (E08.-)")
• Type 1 Excludes: E13 Other specified diabetes mellitus ("diabetes mellitus due to underlying condition (E08.-)")
• Type 1 Excludes: E74 Other disorders of carbohydrate metabolism ("diabetes mellitus (E08-E13)")
• Type 2 Excludes: E87.0 Hyperosmolality and hypernatremia ("diabetes with hyperosmolarity (E08, E09, E11, E13 with final characters .00 or .01)")
• Type 1 Excludes: E87.2 Acidosis ("diabetic acidosis - see categories E08-E10, E11, E13 with ketoacidosis")
• Type 1 Excludes: G54.5 Neuralgic amyotrophy ("neuralgic amyotrophy in diabetes mellitus (E08-E13 with .44)")
• Type 1 Excludes: G59 Mononeuropathy in diseases classified elsewhere ("diabetic mononeuropathy (E08-E13 with .41)")
• Type 1 Excludes: G63 Polyneuropathy in diseases classified elsewhere ("diabetes mellitus (E08-E13 with .42)")
• Type 1 Excludes: G99.0 Autonomic neuropathy in diseases classified elsewhere ("diabetic autonomic neuropathy (E08-E13 with .43)")
• Type 1 Excludes: H20.0 Acute and subacute iridocyclitis ("iridocyclitis, iritis, uveitis (due to) (in) diabetes mellitus (E08-E13 with .39)")
• Type 1 Excludes: I73.8 Other specified peripheral vascular diseases ("diabetic (peripheral) angiopathy (E08-E13 with .51-.52)")
• Type 1 Excludes: I79.8 Other disorders of arteries, arterioles and capillaries in diseases classified elsewhere ("diabetic (peripheral) angiopathy (E08-E13 with .51-.52)")
• Type 2 Excludes: I96 Gangrene, not elsewhere classified ("gangrene in diabetes mellitus (E08-E13 with .52)")
• Type 1 Excludes: L92.1 Necrobiosis lipoidica, not elsewhere classified ("necrobiosis lipoidica associated with diabetes mellitus (E08-E13 with .620)")
• Type 1 Excludes: L99 Other disorders of skin and subcutaneous tissue in diseases classified elsewhere ("skin disorders in diabetes (E08-E13 with .62-)")
• Type 1 Excludes: M14 Arthropathies in other diseases classified elsewhere ("diabetes mellitus (E08-E13 with .61-)")
• Type 1 Excludes: M14.6 Charcôt's joint ("Charcôt's joint in diabetes mellitus (E08-E13 with .610)")
• Type 1 Excludes: M90 Osteopathies in diseases classified elsewhere ("diabetes mellitus (E08-E13 with .69-)")
• Type 1 Excludes: N08 Glomerular disorders in diseases classified elsewhere ("diabetes (E08-E13 with .21)")
• Type 1 Excludes: N16 Renal tubulo-interstitial disorders in diseases classified elsewhere ("renal tubular degeneration in diabetes (E08-E13 with .29)")
• Type 1 Excludes: N76.82 Fournier disease of vagina and vulva ("gangrene in diabetes mellitus (E08-E13 with .52)")
• Code Also: N76.82 Fournier disease of vagina and vulva (", if applicable, diabetes mellitus (E08-E13 with .9)")
• Use Additional: O24.8 Other pre-existing diabetes mellitus in pregnancy, childbirth, and the puerperium ("from categories E08, E09 and E13 to further identify any manifestation")
• Use Additional: O24.9 Unspecified diabetes mellitus in pregnancy, childbirth and the puerperium ("from categories E08, E09 and E13 to further identify any manifestation")
• Type 2 Excludes: R11.15 Cyclical vomiting syndrome unrelated to migraine ("diabetes mellitus due to underlying condition (E08.-)")
• Type 1 Excludes: R40 Somnolence, stupor and coma ("somnolence, stupor and coma in diabetes (E08-E13)")
• Type 1 Excludes: R73 Elevated blood glucose level ("diabetes mellitus (E08-E13)")
• Type 1 Excludes: R73.0 Abnormal glucose ("diabetes mellitus (E08-E13)")

Diagnosis Index entries for E08.641

• Diabetes, diabetic (mellitus) (sugar) › due to underlying condition › with › hypoglycemia › with coma

Nearby codes

• E08.628 Diabetes mellitus due to underlying condition with other skin complications
• E08.63 Diabetes mellitus due to underlying condition with oral complications
• E08.630 Diabetes mellitus due to underlying condition with periodontal disease
• E08.638 Diabetes mellitus due to underlying condition with other oral complications
• E08.64 Diabetes mellitus due to underlying condition with hypoglycemia
• E08.641 Diabetes mellitus due to underlying condition with hypoglycemia with coma (this code)
• E08.649 Diabetes mellitus due to underlying condition with hypoglycemia without coma
• E08.65 Diabetes mellitus due to underlying condition with hyperglycemia
• E08.69 Diabetes mellitus due to underlying condition with other specified complication
• E08.8 Diabetes mellitus due to underlying condition with unspecified complications
• E08.9 Diabetes mellitus due to underlying condition without complications