E22.0 Acromegaly and pituitary gigantism

Billable ICD-10-CM code, FY2026.

Applicable to

• Overproduction of growth hormone

Excludes1 (never code together)

• constitutional gigantism (E34.4)
• constitutional tall stature (E34.4)
• increased secretion from endocrine pancreas of growth hormone-releasing hormone (E16.8)

Applies from E22 Hyperfunction of pituitary gland

Excludes1 (never code together)

• Cushing's syndrome (E24.-)
• Nelson's syndrome (E24.1)
• overproduction of ACTH not associated with Cushing's disease (E27.0)
• overproduction of pituitary ACTH (E24.0)
• overproduction of thyroid-stimulating hormone (E05.8-)

Risk adjustment (HCC)

• CMS-HCC V28: HCC 51 — Addison's and Cushing's Diseases, Acromegaly, and Other Specified Endocrine Disorders
• CMS-HCC V22: HCC 23 — Other Significant Endocrine and Metabolic Disorders
• RxHCC V08: HCC 42 — Acromegaly and Other Endocrine and Metabolic Disorders
• ESRD V24: HCC 23

MS-DRG index

Defines the logic of DRG(s) 643-645 in MDC 10.

Approximate ICD-9-CM (GEMs)

• 253.0 Acromegaly and gigantism (approximate)

Code annotations containing back-references to E22.0

Back-references to E22.0

• Type 1 Excludes: M26.0 Major anomalies of jaw size ("acromegaly (E22.0)")

Back-references to E22

• Code First: G63 Polyneuropathy in diseases classified elsewhere ("endocrine disease, except diabetes (E00-E07, E15-E16, E20-E34)")

Diagnosis Index entries for E22.0

• Acromegaly, acromegalia
• Arthritis, arthritic (acute) (chronic) (nonpyogenic) (subacute) › due to or associated with › acromegaly
• Arthritis, arthritic (acute) (chronic) (nonpyogenic) (subacute) › in (due to) › acromegaly
• Arthropathy › in (due to) › acromegaly
• Erdheim's syndrome (acromegalic macrospondylitis)
• Gigantism (cerebral) (hypophyseal) (pituitary)
• Hypersecretion › hormone (s) › growth
• Hypophyseal, hypophysis › gigantism
• Launois' syndrome (pituitary gigantism)
• Macrospondylitis , acromegalic
• Marie's › disease or syndrome (acromegaly)
• Overproduction › growth hormone
• Scaglietti-Dagnini syndrome
• Syndrome › cerebral › gigantism
• Syndrome › costovertebral
• Syndrome › Erdheim's
• Syndrome › Launois'
• Syndrome › Marie's (acromegaly)
• Syndrome › pituitary
• Syndrome › Scaglietti-Dagnini

Nearby codes

• E22 Hyperfunction of pituitary gland
• E22.0 Acromegaly and pituitary gigantism (this code)
• E22.1 Hyperprolactinemia
• E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
• E22.8 Other hyperfunction of pituitary gland
• E22.9 Hyperfunction of pituitary gland, unspecified