`E22.2` Syndrome of inappropriate secretion of antidiuretic hormone

Billable ICD-10-CM code, FY2026. Acts as a Complication or Comorbidity (CC) as a secondary diagnosis.

Cushing's syndrome (E24.-)
Nelson's syndrome (E24.1)
overproduction of ACTH not associated with Cushing's disease (E27.0)
overproduction of pituitary ACTH (E24.0)
overproduction of thyroid-stimulating hormone (E05.8-)

Risk adjustment (HCC)

CMS-HCC V22: HCC 23 — Other Significant Endocrine and Metabolic Disorders
RxHCC V08: HCC 43 — Pituitary, Adrenal Gland, and Other Endocrine and Metabolic Disorders
ESRD V24: HCC 23

Defines the logic of DRG(s) 643-645 in MDC 10.

Type 1 Excludes: E87.1 Hypo-osmolality and hyponatremia ("syndrome of inappropriate secretion of antidiuretic hormone (E22.2)")

Code First: G63 Polyneuropathy in diseases classified elsewhere ("endocrine disease, except diabetes (E00-E07, E15-E16, E20-E34)")

Antidiuretic hormone syndrome
Hypersecretion › hormone (s) › antidiuretic
Inappropriate › secretion › antidiuretic hormone (ADH) (excessive)
Inappropriate › secretion › pituitary (posterior)
Increase, increased › function › pituitary (gland) (anterior) (lobe) › posterior
Perversion, perverted › function › pituitary gland › posterior lobe
Schwartz-Bartter syndrome
Secretion › antidiuretic hormone, inappropriate
Secretion › hormone › antidiuretic, inappropriate (syndrome)
Syndrome › inappropriate secretion of antidiuretic hormone
Syndrome › Schwartz-Bartter