E22.1 Hyperprolactinemia

Billable ICD-10-CM code, FY2026. Acts as a Complication or Comorbidity (CC) as a secondary diagnosis.

Use additional code

• code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)

Applies from E22 Hyperfunction of pituitary gland

Excludes1 (never code together)

• Cushing's syndrome (E24.-)
• Nelson's syndrome (E24.1)
• overproduction of ACTH not associated with Cushing's disease (E27.0)
• overproduction of pituitary ACTH (E24.0)
• overproduction of thyroid-stimulating hormone (E05.8-)

Risk adjustment (HCC)

• CMS-HCC V22: HCC 23 — Other Significant Endocrine and Metabolic Disorders
• RxHCC V08: HCC 43 — Pituitary, Adrenal Gland, and Other Endocrine and Metabolic Disorders
• ESRD V24: HCC 23

MS-DRG index

Defines the logic of DRG(s) 643-645 in MDC 10.

Approximate ICD-9-CM (GEMs)

• 253.1 Other and unspecified anterior pituitary hyperfunction (approximate)

Code annotations containing back-references to E22.1

Back-references to E22

• Code First: G63 Polyneuropathy in diseases classified elsewhere ("endocrine disease, except diabetes (E00-E07, E15-E16, E20-E34)")

Diagnosis Index entries for E22.1

• Hyperprolactinemia

Nearby codes

• E22 Hyperfunction of pituitary gland
• E22.0 Acromegaly and pituitary gigantism
• E22.1 Hyperprolactinemia (this code)
• E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
• E22.8 Other hyperfunction of pituitary gland
• E22.9 Hyperfunction of pituitary gland, unspecified