E70.41 Histidinemia

Billable ICD-10-CM code, FY2026. Acts as a Complication or Comorbidity (CC) as a secondary diagnosis.

Risk adjustment (HCC)

• CMS-HCC V22: HCC 23 — Other Significant Endocrine and Metabolic Disorders
• RxHCC V08: HCC 43 — Pituitary, Adrenal Gland, and Other Endocrine and Metabolic Disorders
• ESRD V24: HCC 23

MS-DRG index

Defines the logic of DRG(s) 642 in MDC 10.

Approximate ICD-9-CM (GEMs)

• 270.5 Disturbances of histidine metabolism (approximate)

Code annotations containing back-references to E70.41

Back-references to E70

• Type 1 Excludes: E72 Other disorders of amino-acid metabolism ("aromatic amino-acid metabolism (E70.-)")
• Type 2 Excludes: G11 Hereditary ataxia ("metabolic disorders (E70-E88)")
• Code First: G63 Polyneuropathy in diseases classified elsewhere ("metabolic diseases (E70-E88)")
• Type 2 Excludes: G71 Primary disorders of muscles ("metabolic disorders (E70-E88)")
• Code First: H42 Glaucoma in diseases classified elsewhere ("specified metabolic disorder (E70-E88)")
• Type 2 Excludes: N25.0 Renal osteodystrophy ("metabolic disorders classifiable to E70-E88")
• Type 2 Excludes: N25.81 Secondary hyperparathyroidism of renal origin ("metabolic disorders classifiable to E70-E88")
• Type 1 Excludes: P59 Neonatal jaundice from other and unspecified causes ("jaundice due to inborn errors of metabolism (E70-E88)")
• Type 1 Excludes: R79 Other abnormal findings of blood chemistry ("specific findings indicating disorder of amino-acid metabolism (E70-E72)")
• Type 1 Excludes: R79.83 Abnormal findings of blood amino-acid level ("disorders of amino-acid metabolism (E70-E72)")

Diagnosis Index entries for E70.41

• Disorder (of) › histidine metabolism › histidinemia
• Disorder (of) › metabolism NOS › amino-acid › aromatic › histidine › histidinemia
• Histidinemia, histidinuria
• Hyperhistidinemia

Nearby codes

• E70.338 Other albinism with hematologic abnormality
• E70.339 Albinism with hematologic abnormality, unspecified
• E70.39 Other specified albinism
• E70.4 Disorders of histidine metabolism
• E70.40 Disorders of histidine metabolism, unspecified
• E70.41 Histidinemia (this code)
• E70.49 Other disorders of histidine metabolism
• E70.5 Disorders of tryptophan metabolism
• E70.8 Other disorders of aromatic amino-acid metabolism
• E70.81 Aromatic L-amino acid decarboxylase deficiency
• E70.89 Other disorders of aromatic amino-acid metabolism