E72.59 Other disorders of glycine metabolism

Billable ICD-10-CM code, FY2026. Acts as a Complication or Comorbidity (CC) as a secondary diagnosis.

Applicable to

• D-glycericacidemia
• Hyperhydroxyprolinemia
• Hyperprolinemia (types I, II)
• Sarcosinemia

Applies from E72 Other disorders of amino-acid metabolism

Excludes1 (never code together)

• disorders of:
• aromatic amino-acid metabolism (E70.-)
• branched-chain amino-acid metabolism (E71.0-E71.2)
• fatty-acid metabolism (E71.3)
• purine and pyrimidine metabolism (E79.-)
• gout (M1A.-, M10.-)

Risk adjustment (HCC)

• CMS-HCC V22: HCC 23 — Other Significant Endocrine and Metabolic Disorders
• RxHCC V08: HCC 43 — Pituitary, Adrenal Gland, and Other Endocrine and Metabolic Disorders
• ESRD V24: HCC 23

MS-DRG index

Defines the logic of DRG(s) 642 in MDC 10.

Approximate ICD-9-CM (GEMs)

• 270.7 Other disturbances of straight-chain amino-acid metabolism (approximate)

Code annotations containing back-references to E72.59

Back-references to E72

• Type 2 Excludes: G11 Hereditary ataxia ("metabolic disorders (E70-E88)")
• Code First: G63 Polyneuropathy in diseases classified elsewhere ("metabolic diseases (E70-E88)")
• Type 2 Excludes: G71 Primary disorders of muscles ("metabolic disorders (E70-E88)")
• Code First: H42 Glaucoma in diseases classified elsewhere ("specified metabolic disorder (E70-E88)")
• Type 2 Excludes: N25.0 Renal osteodystrophy ("metabolic disorders classifiable to E70-E88")
• Type 2 Excludes: N25.81 Secondary hyperparathyroidism of renal origin ("metabolic disorders classifiable to E70-E88")
• Type 1 Excludes: P59 Neonatal jaundice from other and unspecified causes ("jaundice due to inborn errors of metabolism (E70-E88)")
• Type 1 Excludes: R79 Other abnormal findings of blood chemistry ("specific findings indicating disorder of amino-acid metabolism (E70-E72)")
• Type 1 Excludes: R79.83 Abnormal findings of blood amino-acid level ("disorders of amino-acid metabolism (E70-E72)")

Diagnosis Index entries for E72.59

• d-glycericacidemia
• Disorder (of) › glycine metabolism › d-glycericacidemia
• Disorder (of) › glycine metabolism › hyperhydroxyprolinemia
• Disorder (of) › glycine metabolism › hyperprolinemia
• Disorder (of) › glycine metabolism › sarcosinemia
• Disorder (of) › metabolism NOS › amino-acid › glycine › d-glycericacidemia
• Disorder (of) › metabolism NOS › amino-acid › glycine › hyperhydroxyprolinemia
• Disorder (of) › metabolism NOS › amino-acid › glycine › hyperprolinemia
• Disorder (of) › metabolism NOS › amino-acid › glycine › other specified
• Disorder (of) › metabolism NOS › amino-acid › glycine › sarcosinemia
• Hydroxyprolinemia
• Hyperhydroxyprolinemia
• Hyperprolinemia (type I) (type II)
• Sarcosinemia

Nearby codes

• E72.54 Secondary hyperoxaluria
• E72.540 Dietary hyperoxaluria
• E72.541 Enteric hyperoxaluria
• E72.548 Other secondary hyperoxaluria
• E72.549 Secondary hyperoxaluria, unspecified
• E72.59 Other disorders of glycine metabolism (this code)
• E72.8 Other specified disorders of amino-acid metabolism
• E72.81 Disorders of gamma aminobutyric acid metabolism
• E72.89 Other specified disorders of amino-acid metabolism
• E72.9 Disorder of amino-acid metabolism, unspecified