E72.89 Other specified disorders of amino-acid metabolism

Billable ICD-10-CM code, FY2026. Acts as a Complication or Comorbidity (CC) as a secondary diagnosis.

Applicable to

• Disorders of beta-amino-acid metabolism
• Disorders of gamma-glutamyl cycle

Applies from E72 Other disorders of amino-acid metabolism

Excludes1 (never code together)

• disorders of:
• aromatic amino-acid metabolism (E70.-)
• branched-chain amino-acid metabolism (E71.0-E71.2)
• fatty-acid metabolism (E71.3)
• purine and pyrimidine metabolism (E79.-)
• gout (M1A.-, M10.-)

Risk adjustment (HCC)

• CMS-HCC V22: HCC 23 — Other Significant Endocrine and Metabolic Disorders
• RxHCC V08: HCC 43 — Pituitary, Adrenal Gland, and Other Endocrine and Metabolic Disorders
• ESRD V24: HCC 23

MS-DRG index

Defines the logic of DRG(s) 642 in MDC 10.

Code annotations containing back-references to E72.89

Back-references to E72

• Type 2 Excludes: G11 Hereditary ataxia ("metabolic disorders (E70-E88)")
• Code First: G63 Polyneuropathy in diseases classified elsewhere ("metabolic diseases (E70-E88)")
• Type 2 Excludes: G71 Primary disorders of muscles ("metabolic disorders (E70-E88)")
• Code First: H42 Glaucoma in diseases classified elsewhere ("specified metabolic disorder (E70-E88)")
• Type 2 Excludes: N25.0 Renal osteodystrophy ("metabolic disorders classifiable to E70-E88")
• Type 2 Excludes: N25.81 Secondary hyperparathyroidism of renal origin ("metabolic disorders classifiable to E70-E88")
• Type 1 Excludes: P59 Neonatal jaundice from other and unspecified causes ("jaundice due to inborn errors of metabolism (E70-E88)")
• Type 1 Excludes: R79 Other abnormal findings of blood chemistry ("specific findings indicating disorder of amino-acid metabolism (E70-E72)")
• Type 1 Excludes: R79.83 Abnormal findings of blood amino-acid level ("disorders of amino-acid metabolism (E70-E72)")

Diagnosis Index entries for E72.89

• Disorder (of) › amino-acid › metabolism › specified NEC
• Disorder (of) › beta-amino-acid metabolism
• Disorder (of) › gamma-glutamyl cycle
• Disorder (of) › metabolism NOS › amino-acid › other specified
• Disorder (of) › metabolism NOS › amino-acid › other specified › beta-amino acid
• Disorder (of) › metabolism NOS › amino-acid › other specified › gamma-glutamyl cycle
• Disorder (of) › metabolism NOS › amino-acid › straight-chain
• Disorder (of) › metabolism NOS › glutamine
• Disorder (of) › metabolism NOS › serine
• Disorder (of) › metabolism NOS › threonine
• Disturbance (s) › metabolism › amino-acid › straight-chain
• Disturbance (s) › metabolism › glutamine
• Disturbance (s) › metabolism › threonine
• Syndrome › fish odor

Nearby codes

• E72.548 Other secondary hyperoxaluria
• E72.549 Secondary hyperoxaluria, unspecified
• E72.59 Other disorders of glycine metabolism
• E72.8 Other specified disorders of amino-acid metabolism
• E72.81 Disorders of gamma aminobutyric acid metabolism
• E72.89 Other specified disorders of amino-acid metabolism (this code)
• E72.9 Disorder of amino-acid metabolism, unspecified