E78.00 Pure hypercholesterolemia, unspecified

Billable ICD-10-CM code, FY2026.

Applicable to

• Fredrickson's hyperlipoproteinemia, type IIa
• Hyperbetalipoproteinemia
• Low-density-lipoprotein-type [LDL] hyperlipoproteinemia
• (Pure) hypercholesterolemia NOS

Applies from E78 Disorders of lipoprotein metabolism and other lipidemias

Excludes1 (never code together)

• sphingolipidosis (E75.0-E75.3)

Risk adjustment (HCC)

• RxHCC V08: HCC 47 — Disorders of Lipoid Metabolism

MS-DRG index

Defines the logic of DRG(s) 642 in MDC 10.

Approximate ICD-9-CM (GEMs)

• 272.0 Pure hypercholesterolemia (approximate)

Code annotations containing back-references to E78.00

Back-references to E78

• Type 2 Excludes: E88.0 Disorders of plasma-protein metabolism, not elsewhere classified ("disorder of lipoprotein metabolism (E78.-)")
• Type 2 Excludes: G11 Hereditary ataxia ("metabolic disorders (E70-E88)")
• Code First: G63 Polyneuropathy in diseases classified elsewhere ("metabolic diseases (E70-E88)")
• Type 2 Excludes: G71 Primary disorders of muscles ("metabolic disorders (E70-E88)")
• Code First: H42 Glaucoma in diseases classified elsewhere ("specified metabolic disorder (E70-E88)")
• Type 2 Excludes: N25.0 Renal osteodystrophy ("metabolic disorders classifiable to E70-E88")
• Type 2 Excludes: N25.81 Secondary hyperparathyroidism of renal origin ("metabolic disorders classifiable to E70-E88")
• Type 1 Excludes: P59 Neonatal jaundice from other and unspecified causes ("jaundice due to inborn errors of metabolism (E70-E88)")

Diagnosis Index entries for E78.00

• Cholesteremia
• Cholesterol › elevated (high)
• Cholesterolemia (essential) (pure)
• Elevated, elevation › cholesterol
• Findings, abnormal, inconclusive, without diagnosis › cholesterol › high
• Frederickson's hyperlipoproteinemia, type › IIA
• High › cholesterol
• Hyperbetalipoproteinemia (familial)
• Hypercholesterolemia (essential) (primary) (pure)
• Hyperlipemia, hyperlipidemia › group › A
• Hyperlipoproteinemia › Fredrickson's type › IIa
• Hyperlipoproteinemia › low-density-lipoprotein-type (LDL)
• Low-density-lipoprotein-type (LDL) hyperlipoproteinemia
• Xanthoma (s), xanthomatosis (primary) (familial) (hereditary) › hypercholesterinemic
• Xanthoma (s), xanthomatosis (primary) (familial) (hereditary) › hypercholesterolemic

Nearby codes

• E78 Disorders of lipoprotein metabolism and other lipidemias
• E78.0 Pure hypercholesterolemia
• E78.00 Pure hypercholesterolemia, unspecified (this code)
• E78.01 Familial hypercholesterolemia
• E78.010 Homozygous familial hypercholesterolemia [HoFH]
• E78.011 Heterozygous familial hypercholesterolemia [HeFH]
• E78.019 Familial hypercholesterolemia, unspecified
• E78.1 Pure hyperglyceridemia