E78.6 Lipoprotein deficiency

Billable ICD-10-CM code, FY2026.

Applicable to

• Abetalipoproteinemia
• Depressed HDL cholesterol
• High-density lipoprotein deficiency
• Hypoalphalipoproteinemia
• Hypobetalipoproteinemia (familial)
• Lecithin cholesterol acyltransferase deficiency
• Tangier disease

Applies from E78 Disorders of lipoprotein metabolism and other lipidemias

Excludes1 (never code together)

• sphingolipidosis (E75.0-E75.3)

Risk adjustment (HCC)

• RxHCC V08: HCC 47 — Disorders of Lipoid Metabolism

MS-DRG index

Defines the logic of DRG(s) 642 in MDC 10.

Approximate ICD-9-CM (GEMs)

• 272.5 Lipoprotein deficiencies

Code annotations containing back-references to E78.6

Back-references to E78

• Type 2 Excludes: E88.0 Disorders of plasma-protein metabolism, not elsewhere classified ("disorder of lipoprotein metabolism (E78.-)")
• Type 2 Excludes: G11 Hereditary ataxia ("metabolic disorders (E70-E88)")
• Code First: G63 Polyneuropathy in diseases classified elsewhere ("metabolic diseases (E70-E88)")
• Type 2 Excludes: G71 Primary disorders of muscles ("metabolic disorders (E70-E88)")
• Code First: H42 Glaucoma in diseases classified elsewhere ("specified metabolic disorder (E70-E88)")
• Type 2 Excludes: N25.0 Renal osteodystrophy ("metabolic disorders classifiable to E70-E88")
• Type 2 Excludes: N25.81 Secondary hyperparathyroidism of renal origin ("metabolic disorders classifiable to E70-E88")
• Type 1 Excludes: P59 Neonatal jaundice from other and unspecified causes ("jaundice due to inborn errors of metabolism (E70-E88)")

Diagnosis Index entries for E78.6

• Abetalipoproteinemia
• Acanthocytosis
• Analphalipoproteinemia
• Bassen-Kornzweig disease or syndrome
• Deficiency, deficient › lecithin cholesterol acyltransferase
• Deficiency, deficient › lipoprotein (familial) (high density)
• Depressed › HDL cholesterol
• Disease, diseased › Tangier
• Disorder (of) › glomerular (in) › familial lecithin cholesterol acyltransferase deficiency
• Disorder (of) › lipoprotein › deficiency (familial)
• Dyslipidemia › depressed HDL cholesterol
• Glomerulonephritis › in (due to) › lecithin cholesterol acyltransferase deficiency
• Hypoalphalipoproteinemia
• Hypobetalipoproteinemia (familial)
• Hypolipoproteinemia (alpha) (beta)
• Tangier disease

Nearby codes

• E78.3 Hyperchylomicronemia
• E78.4 Other hyperlipidemia
• E78.41 Elevated Lipoprotein(a)
• E78.49 Other hyperlipidemia
• E78.5 Hyperlipidemia, unspecified
• E78.6 Lipoprotein deficiency (this code)
• E78.7 Disorders of bile acid and cholesterol metabolism
• E78.70 Disorder of bile acid and cholesterol metabolism, unspecified
• E78.71 Barth syndrome
• E78.72 Smith-Lemli-Opitz syndrome
• E78.79 Other disorders of bile acid and cholesterol metabolism