K72.91 Hepatic failure, unspecified with coma

Billable ICD-10-CM code, FY2026. Acts as a Major Complication or Comorbidity (MCC) as a secondary diagnosis.

Applicable to

• Hepatic coma NOS

Applies from K72 Hepatic failure, not elsewhere classified

Includes

• fulminant hepatitis NEC, with hepatic failure
• liver (cell) necrosis with hepatic failure
• malignant hepatitis NEC, with hepatic failure
• yellow liver atrophy or dystrophy

Excludes1 (never code together)

• alcoholic hepatic failure (K70.4)
• hepatic failure with toxic liver disease (K71.1-)
• icterus of newborn (P55-P59)
• postprocedural hepatic failure (K91.82)

Excludes2 (not included here)

• hepatic failure complicating abortion or ectopic or molar pregnancy (O00-O07, O08.8)
• hepatic failure complicating pregnancy, childbirth and the puerperium (O26.6-)
• viral hepatitis with hepatic coma (B15-B19)

Use additional code

• code, if applicable, for ascites (R18.8)

Risk adjustment (HCC)

• CMS-HCC V28: HCC 63 — Chronic Liver Failure/End-Stage Liver Disorders
• CMS-HCC V22: HCC 27 — End-Stage Liver Disease
• ESRD V24: HCC 27

MS-DRG index

Defines the logic of DRG(s) 441-443 in MDC 07.

Approximate ICD-9-CM (GEMs)

• 572.2 Hepatic encephalopathy (approximate)
• 572.2 Hepatic encephalopathy (approximate)
• 572.8 Other sequelae of chronic liver disease (approximate)

Code annotations containing back-references to K72.91

Back-references to K72.91

• Type 1 Excludes: K76.82 Hepatic encephalopathy ("hepatic failure with coma (K72.91)")

Back-references to K72

• Type 1 Excludes: K76.2 Central hemorrhagic necrosis of liver ("liver necrosis with hepatic failure (K72.-)")
• Use Additional: M31.11 Hematopoietic stem cell transplantation-associated thrombotic microangiopathy [HSCT-TMA] ("hepatic failure (K72.-)")
• Type 1 Excludes: R40 Somnolence, stupor and coma ("somnolence, stupor and coma in hepatic failure (K72.-)")

Diagnosis Index entries for K72.91

• Atrophy, atrophic (of) › liver (yellow) › with coma
• Failure, failed › hepatic › with coma
• Hepatitis › malignant NEC (with hepatic failure) › with coma
• Impaired, impairment (function) › liver › with coma
• Jaundice (yellow) › malignant (without coma) › with coma

Nearby codes

• K72.1 Chronic hepatic failure
• K72.10 Chronic hepatic failure without coma
• K72.11 Chronic hepatic failure with coma
• K72.9 Hepatic failure, unspecified
• K72.90 Hepatic failure, unspecified without coma
• K72.91 Hepatic failure, unspecified with coma (this code)