D57.3 Sickle-cell trait

Billable ICD-10-CM code, FY2026.

Applicable to

• Hb-S trait
• Heterozygous hemoglobin S

Applies from D57 Sickle-cell disorders

Excludes1 (never code together)

• other hemoglobinopathies (D58.-)

Use additional code

• code for any associated fever (R50.81)

Risk adjustment (HCC)

• CMS-HCC V22: HCC 48 — Coagulation Defects and Other Specified Hematological Disorders
• ESRD V24: HCC 48

MS-DRG index

Defines the logic of DRG(s) 811-812 in MDC 16.

Approximate ICD-9-CM (GEMs)

• 282.5 Sickle-cell trait

Code annotations containing back-references to D57.3

Back-references to D57.3

• Type 1 Excludes: D56.3 Thalassemia minor ("sickle-cell trait (D57.3)")
• Code First: N08 Glomerular disorders in diseases classified elsewhere ("sickle-cell disease (D57.0-D57.8)")

Back-references to D57

• Type 1 Excludes: D56.8 Other thalassemias ("sickle-cell anemia (D57.-)")
• Code First: H36 Retinal disorders in diseases classified elsewhere ("sickle-cell disorders (D57.-)")
• Code First: M14.8 Arthropathies in other specified diseases classified elsewhere ("sickle-cell disorders (D57.-)")
• Code First: M90.5 Osteonecrosis in diseases classified elsewhere ("hemoglobinopathy (D50-D64)")
• Code First: R50.81 Fever presenting with conditions classified elsewhere ("sickle-cell disease (D57.-)")
• Type 1 Excludes: R71 Abnormality of red blood cells ("anemias (D50-D64)")
• Code Also: Z71.87 Encounter for pediatric-to-adult transition counseling ("sickle-cell disorder (D57.-)")

Diagnosis Index entries for D57.3

• Disease, diseased › hemoglobin or Hb › AS genotype
• Disorder (of) › sickle-cell (sickling) (homozygous) › heterozygous
• Disorder (of) › sickle-cell (sickling) (homozygous) › trait
• Elliptocytosis (congenital) (hereditary) › sickle-cell (disease) › trait
• Hemoglobin › AS genotype
• Hemoglobin › S (Hb S), heterozygous
• Sickle-cell › trait
• Sicklemia › trait
• Trait (s) › Hb-S
• Trait (s) › hemoglobin › S (Hb-S)
• Trait (s) › sickle-cell
• Trait (s) › sickle-cell › with elliptocytosis or spherocytosis

Nearby codes

• D57.212 Sickle-cell/Hb-C disease with splenic sequestration
• D57.213 Sickle-cell/Hb-C disease with cerebral vascular involvement
• D57.214 Sickle-cell/Hb-C disease with dactylitis
• D57.218 Sickle-cell/Hb-C disease with crisis with other specified complication
• D57.219 Sickle-cell/Hb-C disease with crisis, unspecified
• D57.3 Sickle-cell trait (this code)
• D57.4 Sickle-cell thalassemia
• D57.40 Sickle-cell thalassemia without crisis
• D57.41 Sickle-cell thalassemia, unspecified, with crisis
• D57.411 Sickle-cell thalassemia, unspecified, with acute chest syndrome
• D57.412 Sickle-cell thalassemia, unspecified, with splenic sequestration