D57.40 Sickle-cell thalassemia without crisis

Billable ICD-10-CM code, FY2026.

Applicable to

• Microdrepanocytosis
• Sickle-cell thalassemia NOS

Applies from D57 Sickle-cell disorders

Excludes1 (never code together)

• other hemoglobinopathies (D58.-)

Use additional code

• code for any associated fever (R50.81)

Applies from D57.4 Sickle-cell thalassemia

Applicable to

• Sickle-cell beta thalassemia
• Thalassemia Hb-S disease

Risk adjustment (HCC)

• CMS-HCC V28: HCC 108 — Sickle Cell Disorders, Except Sickle Cell Anemia (Hb-SS) and Thalassemia Beta Zero; Beta Thalassemia Major
• CMS-HCC V22: HCC 46 — Severe Hematological Disorders
• ESRD V24: HCC 46

MS-DRG index

Defines the logic of DRG(s) 791 in MDC 15.

Approximate ICD-9-CM (GEMs)

• 282.41 Sickle-cell thalassemia without crisis

Code annotations containing back-references to D57.40

Back-references to D57.4

• Type 1 Excludes: D56 Thalassemia ("sickle-cell thalassemia (D57.4-)")
• Type 1 Excludes: D56.1 Beta thalassemia ("sickle-cell beta thalassemia (D57.4-)")
• Type 1 Excludes: D56.5 Hemoglobin E-beta thalassemia ("sickle-cell beta thalassemia (D57.4-)")
• Type 1 Excludes: D56.8 Other thalassemias ("sickle-cell thalassemia (D57.4-)")
• Code First: N08 Glomerular disorders in diseases classified elsewhere ("sickle-cell disease (D57.0-D57.8)")

Back-references to D57

• Type 1 Excludes: D56.8 Other thalassemias ("sickle-cell anemia (D57.-)")
• Code First: H36 Retinal disorders in diseases classified elsewhere ("sickle-cell disorders (D57.-)")
• Code First: M14.8 Arthropathies in other specified diseases classified elsewhere ("sickle-cell disorders (D57.-)")
• Code First: M90.5 Osteonecrosis in diseases classified elsewhere ("hemoglobinopathy (D50-D64)")
• Code First: R50.81 Fever presenting with conditions classified elsewhere ("sickle-cell disease (D57.-)")
• Type 1 Excludes: R71 Abnormality of red blood cells ("anemias (D50-D64)")
• Code Also: Z71.87 Encounter for pediatric-to-adult transition counseling ("sickle-cell disorder (D57.-)")

Diagnosis Index entries for D57.40

• Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › microdrepanocytosis
• Disease, diseased › sickle-cell › thalassemia
• Disease, diseased › sickle-cell › thalassemia › without crisis
• Hemoglobinopathy (mixed) › sickle-cell › with thalassemia
• Hemoglobinopathy (mixed) › sickle-cell › with thalassemia › without crisis
• Microdrepanocytosis

Nearby codes

• D57.214 Sickle-cell/Hb-C disease with dactylitis
• D57.218 Sickle-cell/Hb-C disease with crisis with other specified complication
• D57.219 Sickle-cell/Hb-C disease with crisis, unspecified
• D57.3 Sickle-cell trait
• D57.4 Sickle-cell thalassemia
• D57.40 Sickle-cell thalassemia without crisis (this code)
• D57.41 Sickle-cell thalassemia, unspecified, with crisis
• D57.411 Sickle-cell thalassemia, unspecified, with acute chest syndrome
• D57.412 Sickle-cell thalassemia, unspecified, with splenic sequestration
• D57.413 Sickle-cell thalassemia, unspecified, with cerebral vascular involvement
• D57.414 Sickle-cell thalassemia, unspecified, with dactylitis