D61.1 Drug-induced aplastic anemia

Billable ICD-10-CM code, FY2026. Acts as a Major Complication or Comorbidity (MCC) as a secondary diagnosis.

Use additional code

• code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)

Applies from D61 Other aplastic anemias and other bone marrow failure syndromes

Excludes2 (not included here)

• neutropenia (D70.-)

Risk adjustment (HCC)

• CMS-HCC V22: HCC 46 — Severe Hematological Disorders
• RxHCC V08: HCC 96 — Acquired Hemolytic, Aplastic, and Sideroblastic Anemias
• ESRD V24: HCC 46

MS-DRG index

Defines the logic of DRG(s) 808-810 in MDC 16.

Approximate ICD-9-CM (GEMs)

• 284.89 Other specified aplastic anemias (approximate)

Code annotations containing back-references to D61.1

Back-references to D61.1

• Type 2 Excludes: D46 Myelodysplastic syndromes ("drug-induced aplastic anemia (D61.1)")
• Type 2 Excludes: D61.810 Antineoplastic chemotherapy induced pancytopenia ("aplastic anemia due to antineoplastic chemotherapy (D61.1)")
• Type 2 Excludes: D61.811 Other drug-induced pancytopenia ("aplastic anemia due to drugs (D61.1)")
• Type 1 Excludes: D63.0 Anemia in neoplastic disease ("aplastic anemia due to antineoplastic chemotherapy (D61.1)")
• Type 2 Excludes: D64.81 Anemia due to antineoplastic chemotherapy ("aplastic anemia due to antineoplastic chemotherapy (D61.1)")

Back-references to D61

• Code First: M90.5 Osteonecrosis in diseases classified elsewhere ("hemoglobinopathy (D50-D64)")
• Type 1 Excludes: R71 Abnormality of red blood cells ("anemias (D50-D64)")

Diagnosis Index entries for D61.1

• Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › aplastic › drug-induced
• Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › aplastic › due to › drugs

Nearby codes

• D61.0 Constitutional aplastic anemia
• D61.01 Constitutional (pure) red blood cell aplasia
• D61.02 Shwachman-Diamond syndrome
• D61.03 Fanconi anemia
• D61.09 Other constitutional aplastic anemia
• D61.1 Drug-induced aplastic anemia (this code)
• D61.2 Aplastic anemia due to other external agents
• D61.3 Idiopathic aplastic anemia
• D61.8 Other specified aplastic anemias and other bone marrow failure syndromes
• D61.81 Pancytopenia
• D61.810 Antineoplastic chemotherapy induced pancytopenia