D61.01 Constitutional (pure) red blood cell aplasia

Billable ICD-10-CM code, FY2026. Acts as a Complication or Comorbidity (CC) as a secondary diagnosis.

Applicable to

• Blackfan-Diamond syndrome
• Congenital (pure) red cell aplasia
• Familial hypoplastic anemia
• Primary (pure) red cell aplasia
• Red cell (pure) aplasia of infants

Excludes1 (never code together)

• acquired red cell aplasia (D60.9)

Applies from D61 Other aplastic anemias and other bone marrow failure syndromes

Excludes2 (not included here)

• neutropenia (D70.-)

Risk adjustment (HCC)

• CMS-HCC V28: HCC 109 — Acquired Hemolytic, Aplastic, and Sideroblastic Anemias
• CMS-HCC V22: HCC 46 — Severe Hematological Disorders
• RxHCC V08: HCC 96 — Acquired Hemolytic, Aplastic, and Sideroblastic Anemias
• ESRD V24: HCC 46

MS-DRG index

Defines the logic of DRG(s) 808-810 in MDC 16.

Approximate ICD-9-CM (GEMs)

• 284.01 Constitutional red blood cell aplasia

Code annotations containing back-references to D61.01

Back-references to D61.01

• Type 1 Excludes: D60 Acquired pure red cell aplasia [erythroblastopenia] ("congenital red cell aplasia (D61.01)")
• Type 1 Excludes: D61.81 Pancytopenia ("pancytopenia (due to) (with) congenital (pure) red cell aplasia (D61.01)")
• Type 1 Excludes: D64.4 Congenital dyserythropoietic anemia ("Blackfan-Diamond syndrome (D61.01)")

Back-references to D61

• Code First: M90.5 Osteonecrosis in diseases classified elsewhere ("hemoglobinopathy (D50-D64)")
• Type 1 Excludes: R71 Abnormality of red blood cells ("anemias (D50-D64)")

Diagnosis Index entries for D61.01

• Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › aplastic › red cell (pure) › congenital
• Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › Diamond-Blackfan (congenital hypoplastic)
• Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › hypoplasia, red blood cells › congenital or familial
• Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › hypoplastic (idiopathic) › congenital or familial (of childhood)
• Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › Joseph-Diamond-Blackfan (congenital hypoplastic)
• Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › pure red cell › congenital
• Aplasia › bone marrow (myeloid) › congenital
• Aplasia › congenital pure red cell
• Aplasia › erythrocyte congenital
• Aplasia › red cell (with thymoma) › congenital
• Aplasia › red cell (with thymoma) › constitutional
• Aplasia › red cell (with thymoma) › hereditary
• Aplasia › red cell (with thymoma) › of infants
• Aplasia › red cell (with thymoma) › primary
• Aplasia › red cell (with thymoma) › pure
• Blackfan-Diamond anemia or syndrome (congenital hypoplastic anemia)
• Diamond-Blackfan anemia (congenital hypoplastic)
• Erythroblastopenia › congenital
• Hypoplasia, hypoplastic › erythroid, congenital
• Joseph-Diamond-Blackfan anemia (congenital hypoplastic)
• Kaznelson's syndrome (congenital hypoplastic anemia)
• Syndrome › Blackfan-Diamond
• Syndrome › Diamond-Blackfan
• Syndrome › Joseph-Diamond-Blackfan

Nearby codes

• D61 Other aplastic anemias and other bone marrow failure syndromes
• D61.0 Constitutional aplastic anemia
• D61.01 Constitutional (pure) red blood cell aplasia (this code)
• D61.02 Shwachman-Diamond syndrome
• D61.03 Fanconi anemia
• D61.09 Other constitutional aplastic anemia
• D61.1 Drug-induced aplastic anemia
• D61.2 Aplastic anemia due to other external agents