E78.2 Mixed hyperlipidemia

Billable ICD-10-CM code, FY2026.

Applicable to

• Broad- or floating-betalipoproteinemia
• Combined hyperlipidemia NOS
• Elevated cholesterol with elevated triglycerides NEC
• Fredrickson's hyperlipoproteinemia, type IIb or III
• Hyperbetalipoproteinemia with prebetalipoproteinemia
• Hypercholesteremia with endogenous hyperglyceridemia
• Hyperlipidemia, group C
• Tubo-eruptive xanthoma
• Xanthoma tuberosum

Excludes1 (never code together)

• cerebrotendinous cholesterosis [van Bogaert-Scherer- Epstein] (E75.5)
• familial combined hyperlipidemia (E78.49)

Applies from E78 Disorders of lipoprotein metabolism and other lipidemias

Excludes1 (never code together)

• sphingolipidosis (E75.0-E75.3)

Risk adjustment (HCC)

• RxHCC V08: HCC 47 — Disorders of Lipoid Metabolism

MS-DRG index

Defines the logic of DRG(s) 642 in MDC 10.

Approximate ICD-9-CM (GEMs)

• 272.2 Mixed hyperlipidemia

Code annotations containing back-references to E78.2

Back-references to E78.2

• Type 1 Excludes: M67 Other disorders of synovium and tendon ("xanthomatosis localized to tendons (E78.2)")

Back-references to E78

• Type 2 Excludes: E88.0 Disorders of plasma-protein metabolism, not elsewhere classified ("disorder of lipoprotein metabolism (E78.-)")
• Type 2 Excludes: G11 Hereditary ataxia ("metabolic disorders (E70-E88)")
• Code First: G63 Polyneuropathy in diseases classified elsewhere ("metabolic diseases (E70-E88)")
• Type 2 Excludes: G71 Primary disorders of muscles ("metabolic disorders (E70-E88)")
• Code First: H42 Glaucoma in diseases classified elsewhere ("specified metabolic disorder (E70-E88)")
• Type 2 Excludes: N25.0 Renal osteodystrophy ("metabolic disorders classifiable to E70-E88")
• Type 2 Excludes: N25.81 Secondary hyperparathyroidism of renal origin ("metabolic disorders classifiable to E70-E88")
• Type 1 Excludes: P59 Neonatal jaundice from other and unspecified causes ("jaundice due to inborn errors of metabolism (E70-E88)")

Diagnosis Index entries for E78.2

• Betalipoproteinemia, broad or floating
• Broad › beta disease
• Broad- or floating-betalipoproteinemia
• Cholesterol › elevated (high) › with elevated (high) triglycerides
• Cirrhosis, cirrhotic (hepatic) (liver) › due to › xanthomatosis
• Cirrhosis, cirrhotic (hepatic) (liver) › xanthomatous (biliary) › due to xanthomatosis (familial) (metabolic) (primary)
• Disease, diseased › broad › beta
• Dysbetalipoproteinemia (familial)
• Elevated, elevation › cholesterol › with high triglycerides
• Elevated, elevation › triglycerides › with high cholesterol
• Findings, abnormal, inconclusive, without diagnosis › cholesterol › high › with high triglycerides
• Findings, abnormal, inconclusive, without diagnosis › triglycerides › high › with high cholesterol
• Frederickson's hyperlipoproteinemia, type › IIB and III
• High › cholesterol › with high triglycerides
• High › triglycerides › with high cholesterol
• Hyperbetalipoproteinemia (familial) › with prebetalipoproteinemia
• Hypercholesterolemia (essential) (primary) (pure) › with hyperglyceridemia, endogenous
• Hyperlipemia, hyperlipidemia › combined
• Hyperlipemia, hyperlipidemia › group › C
• Hyperlipemia, hyperlipidemia › mixed
• Hyperlipoproteinemia › Fredrickson's type › IIb
• Hyperlipoproteinemia › Fredrickson's type › III
• Lipoproteinemia › broad-beta
• Lipoproteinemia › floating-beta
• Xanthelasmatosis (essential)
• Xanthoma (s), xanthomatosis (primary) (familial) (hereditary)
• Xanthoma (s), xanthomatosis (primary) (familial) (hereditary) › with › hyperlipoproteinemia › Type III
• Xanthoma (s), xanthomatosis (primary) (familial) (hereditary) › disseminatum (skin)
• Xanthoma (s), xanthomatosis (primary) (familial) (hereditary) › eruptive
• Xanthoma (s), xanthomatosis (primary) (familial) (hereditary) › multiple (skin)
• Xanthoma (s), xanthomatosis (primary) (familial) (hereditary) › tubo-eruptive
• Xanthoma (s), xanthomatosis (primary) (familial) (hereditary) › tuberosum
• Xanthoma (s), xanthomatosis (primary) (familial) (hereditary) › tuberous

Nearby codes

• E78.01 Familial hypercholesterolemia
• E78.010 Homozygous familial hypercholesterolemia [HoFH]
• E78.011 Heterozygous familial hypercholesterolemia [HeFH]
• E78.019 Familial hypercholesterolemia, unspecified
• E78.1 Pure hyperglyceridemia
• E78.2 Mixed hyperlipidemia (this code)
• E78.3 Hyperchylomicronemia
• E78.4 Other hyperlipidemia
• E78.41 Elevated Lipoprotein(a)
• E78.49 Other hyperlipidemia
• E78.5 Hyperlipidemia, unspecified