E88.3 Tumor lysis syndrome

Billable ICD-10-CM code, FY2026. Acts as a Major Complication or Comorbidity (MCC) as a secondary diagnosis.

Applicable to

• Tumor lysis syndrome (spontaneous)
• Tumor lysis syndrome following antineoplastic drug chemotherapy

Use additional code

• code for adverse effect, if applicable, to identify drug (T45.1X5)

Applies from E88 Other and unspecified metabolic disorders

Excludes1 (never code together)

• histiocytosis X (chronic) (C96.6)

Use additional code

• codes for associated conditions

MS-DRG index

Defines the logic of DRG(s) 673-675 in MDC 11.

Approximate ICD-9-CM (GEMs)

• 277.88 Tumor lysis syndrome

Code annotations containing back-references to E88.3

Back-references to E88

• Type 2 Excludes: G11 Hereditary ataxia ("metabolic disorders (E70-E88)")
• Code First: G63 Polyneuropathy in diseases classified elsewhere ("metabolic diseases (E70-E88)")
• Type 2 Excludes: G71 Primary disorders of muscles ("metabolic disorders (E70-E88)")
• Code First: H42 Glaucoma in diseases classified elsewhere ("specified metabolic disorder (E70-E88)")
• Type 2 Excludes: N25.0 Renal osteodystrophy ("metabolic disorders classifiable to E70-E88")
• Type 2 Excludes: N25.81 Secondary hyperparathyroidism of renal origin ("metabolic disorders classifiable to E70-E88")
• Type 1 Excludes: P59 Neonatal jaundice from other and unspecified causes ("jaundice due to inborn errors of metabolism (E70-E88)")

Diagnosis Index entries for E88.3

• Syndrome › tumor lysis (following antineoplastic chemotherapy) (spontaneous) NEC
• Tumor lysis syndrome (following antineoplastic chemotherapy) (spontaneous) NEC

Nearby codes

• E88.12 Generalized lipodystrophy
• E88.13 Localized lipodystrophy
• E88.14 HIV-associated lipodystrophy
• E88.19 Other lipodystrophy, not elsewhere classified
• E88.2 Lipomatosis, not elsewhere classified
• E88.3 Tumor lysis syndrome (this code)
• E88.4 Mitochondrial metabolism disorders
• E88.40 Mitochondrial metabolism disorder, unspecified
• E88.41 MELAS syndrome
• E88.42 MERRF syndrome
• E88.43 Disorders of mitochondrial tRNA synthetases