K72.01 Acute and subacute hepatic failure with coma

Billable ICD-10-CM code, FY2026. Acts as a Major Complication or Comorbidity (MCC) as a secondary diagnosis.

Applies from K72 Hepatic failure, not elsewhere classified

Includes

• fulminant hepatitis NEC, with hepatic failure
• liver (cell) necrosis with hepatic failure
• malignant hepatitis NEC, with hepatic failure
• yellow liver atrophy or dystrophy

Excludes1 (never code together)

• alcoholic hepatic failure (K70.4)
• hepatic failure with toxic liver disease (K71.1-)
• icterus of newborn (P55-P59)
• postprocedural hepatic failure (K91.82)

Excludes2 (not included here)

• hepatic failure complicating abortion or ectopic or molar pregnancy (O00-O07, O08.8)
• hepatic failure complicating pregnancy, childbirth and the puerperium (O26.6-)
• viral hepatitis with hepatic coma (B15-B19)

Use additional code

• code, if applicable, for ascites (R18.8)

Applies from K72.0 Acute and subacute hepatic failure

Applicable to

• Acute non-viral hepatitis NOS

Risk adjustment (HCC)

• CMS-HCC V22: HCC 27 — End-Stage Liver Disease
• ESRD V24: HCC 27

MS-DRG index

Defines the logic of DRG(s) 441-443 in MDC 07.

Approximate ICD-9-CM (GEMs)

• 570 Acute and subacute necrosis of liver (approximate)
• 572.2 Hepatic encephalopathy (approximate)

Code annotations containing back-references to K72.01

Back-references to K72.01

• Type 1 Excludes: K76.82 Hepatic encephalopathy ("acute and subacute hepatic failure with coma (K72.01)")

Back-references to K72.0

• Type 2 Excludes: K75.0 Abscess of liver ("acute or subacute non-viral hepatitis (K72.0)")
• Type 1 Excludes: K75.2 Nonspecific reactive hepatitis ("acute or subacute hepatitis (K72.0-)")
• Type 1 Excludes: K75.3 Granulomatous hepatitis, not elsewhere classified ("acute or subacute hepatitis (K72.0-)")
• Type 1 Excludes: K75.9 Inflammatory liver disease, unspecified ("acute or subacute hepatitis (K72.0-)")
• Code Also: M35.81 Multisystem inflammatory syndrome ("acute hepatic failure (K72.0-)")
• Use Additional: R65.11 Systemic inflammatory response syndrome (SIRS) of non-infectious origin with acute organ dysfunction ("hepatic failure (K72.0-)")
• Use Additional: R65.2 Severe sepsis ("hepatic failure (K72.0-)")

Back-references to K72

• Type 1 Excludes: K76.2 Central hemorrhagic necrosis of liver ("liver necrosis with hepatic failure (K72.-)")
• Use Additional: M31.11 Hematopoietic stem cell transplantation-associated thrombotic microangiopathy [HSCT-TMA] ("hepatic failure (K72.-)")
• Type 1 Excludes: R40 Somnolence, stupor and coma ("somnolence, stupor and coma in hepatic failure (K72.-)")

Diagnosis Index entries for K72.01

• Atrophy, atrophic (of) › liver (yellow) › acute, subacute › with coma
• Degeneration, degenerative › liver (diffuse) NEC › parenchymatous, acute or subacute › with coma
• Failure, failed › hepatic › acute or subacute › with coma
• Hepatitis › acute › with coma

Nearby codes

• K72 Hepatic failure, not elsewhere classified
• K72.0 Acute and subacute hepatic failure
• K72.00 Acute and subacute hepatic failure without coma
• K72.01 Acute and subacute hepatic failure with coma (this code)
• K72.1 Chronic hepatic failure
• K72.10 Chronic hepatic failure without coma
• K72.11 Chronic hepatic failure with coma
• K72.9 Hepatic failure, unspecified
• K72.90 Hepatic failure, unspecified without coma