E16.1 Other hypoglycemia

Billable ICD-10-CM code, FY2026.

Applicable to

• Functional hyperinsulinism
• Functional nonhyperinsulinemic hypoglycemia
• Hyperinsulinism NOS
• Hyperplasia of pancreatic islet beta cells NOS

Excludes1 (never code together)

• diabetes with hypoglycemia (E08.649, E10.649, E11.649, E13.649)
• hypoglycemia in infant of diabetic mother (P70.1)
• neonatal hypoglycemia (P70.4)

Use additional code

• code for hypoglycemia level, if applicable (E16.A-)

MS-DRG index

Defines the logic of DRG(s) 643-645 in MDC 10.

Approximate ICD-9-CM (GEMs)

• 251.1 Other specified hypoglycemia (approximate)

Code annotations containing back-references to E16.1

Back-references to E16

• Code First: G63 Polyneuropathy in diseases classified elsewhere ("endocrine disease, except diabetes (E00-E07, E15-E16, E20-E34)")

Diagnosis Index entries for E16.1

• Encephalopathy (acute) › in (due to) (with) › hyperinsulinism
• Encephalopathy (acute) › posthypoglycemic (coma)
• Hyperinsulinism (functional)
• Hyperinsulinism (functional) › with › encephalopathy
• Hyperinsulinism (functional) › ectopic
• Hyperplasia, hyperplastic › pancreatic islet cells › beta
• Hypoglycemia (spontaneous) › functional, nonhyperinsulinemic
• Hypoglycemia (spontaneous) › infantile
• Hypoglycemia (spontaneous) › reactive (not drug-induced)

Nearby codes

• E16 Other disorders of pancreatic internal secretion
• E16.0 Drug-induced hypoglycemia without coma
• E16.1 Other hypoglycemia (this code)
• E16.2 Hypoglycemia, unspecified
• E16.3 Increased secretion of glucagon
• E16.4 Increased secretion of gastrin
• E16.8 Other specified disorders of pancreatic internal secretion
• E16.9 Disorder of pancreatic internal secretion, unspecified