E16.3 Increased secretion of glucagon

Billable ICD-10-CM code, FY2026.

Applicable to

• Hyperplasia of pancreatic endocrine cells with glucagon excess

Risk adjustment (HCC)

• RxHCC V08: HCC 66 — Pancreatic Disorders and Intestinal Malabsorption, Except Pancreatitis

MS-DRG index

Defines the logic of DRG(s) 643-645 in MDC 10.

Approximate ICD-9-CM (GEMs)

• 251.4 Abnormality of secretion of glucagon

Code annotations containing back-references to E16.3

Back-references to E16.3

• Type 1 Excludes: E74 Other disorders of carbohydrate metabolism ("increased secretion of glucagon (E16.3)")

Back-references to E16

• Code First: G63 Polyneuropathy in diseases classified elsewhere ("endocrine disease, except diabetes (E00-E07, E15-E16, E20-E34)")

Diagnosis Index entries for E16.3

• Abnormal, abnormality, abnormalities › glucagon secretion
• Abnormal, abnormality, abnormalities › secretion › glucagon
• Excess, excessive, excessively › glucagon
• Hyperplasia, hyperplastic › pancreatic islet cells › alpha › with excess › glucagon
• Hypersecretion › glucagon
• Increase, increased › secretion › glucagon

Nearby codes

• E16 Other disorders of pancreatic internal secretion
• E16.0 Drug-induced hypoglycemia without coma
• E16.1 Other hypoglycemia
• E16.2 Hypoglycemia, unspecified
• E16.3 Increased secretion of glucagon (this code)
• E16.4 Increased secretion of gastrin
• E16.8 Other specified disorders of pancreatic internal secretion
• E16.9 Disorder of pancreatic internal secretion, unspecified
• E16.A Hypoglycemia level
• E16.A1 Hypoglycemia level 1