E16.4 Increased secretion of gastrin

Billable ICD-10-CM code, FY2026.

Applicable to

• Hypergastrinemia
• Hyperplasia of pancreatic endocrine cells with gastrin excess
• Zollinger-Ellison syndrome

Risk adjustment (HCC)

• RxHCC V08: HCC 66 — Pancreatic Disorders and Intestinal Malabsorption, Except Pancreatitis

MS-DRG index

Defines the logic of DRG(s) 380-382 in MDC 06.

Approximate ICD-9-CM (GEMs)

• 251.5 Abnormality of secretion of gastrin

Code annotations containing back-references to E16.4

Back-references to E16.4

• Type 1 Excludes: K29 Gastritis and duodenitis ("Zollinger-Ellison syndrome (E16.4)")

Back-references to E16

• Code First: G63 Polyneuropathy in diseases classified elsewhere ("endocrine disease, except diabetes (E00-E07, E15-E16, E20-E34)")

Diagnosis Index entries for E16.4

• Abnormal, abnormality, abnormalities › gastrin secretion
• Abnormal, abnormality, abnormalities › secretion › gastrin
• Ellison-Zollinger syndrome
• Hypergastrinemia
• Hyperplasia, hyperplastic › pancreatic islet cells › alpha › with excess › gastrin
• Hypersecretion › gastrin
• Increase, increased › secretion › gastrin
• Zollinger-Ellison syndrome

Nearby codes

• E16 Other disorders of pancreatic internal secretion
• E16.0 Drug-induced hypoglycemia without coma
• E16.1 Other hypoglycemia
• E16.2 Hypoglycemia, unspecified
• E16.3 Increased secretion of glucagon
• E16.4 Increased secretion of gastrin (this code)
• E16.8 Other specified disorders of pancreatic internal secretion
• E16.9 Disorder of pancreatic internal secretion, unspecified
• E16.A Hypoglycemia level
• E16.A1 Hypoglycemia level 1
• E16.A2 Hypoglycemia level 2