E85.82 Wild-type transthyretin-related (ATTR) amyloidosis

Billable ICD-10-CM code, FY2026. Acts as a Complication or Comorbidity (CC) as a secondary diagnosis.

Applicable to

• Senile systemic amyloidosis (SSA)

Applies from E85 Amyloidosis

Excludes2 (not included here)

• Alzheimer's disease (G30.0-)

Risk adjustment (HCC)

• CMS-HCC V28: HCC 50 — Amyloidosis, Porphyria, and Other Specified Metabolic Disorders
• CMS-HCC V22: HCC 23 — Other Significant Endocrine and Metabolic Disorders
• ESRD V24: HCC 23

MS-DRG index

Defines the logic of DRG(s) 545-547 in MDC 08.

Approximate ICD-9-CM (GEMs)

• 277.39 Other amyloidosis (approximate)

Code annotations containing back-references to E85.82

Back-references to E85

• Code First: D77 Other disorders of blood and blood-forming organs in diseases classified elsewhere ("amyloidosis (E85.-)")
• Type 1 Excludes: E27.1 Primary adrenocortical insufficiency ("amyloidosis (E85.-)")
• Type 2 Excludes: G11 Hereditary ataxia ("metabolic disorders (E70-E88)")
• Code First: G32.8 Other specified degenerative disorders of nervous system in diseases classified elsewhere ("amyloidosis cerebral degeneration (E85.-)")
• Code First: G63 Polyneuropathy in diseases classified elsewhere ("amyloidosis (E85.-)")
• Code First: G63 Polyneuropathy in diseases classified elsewhere ("metabolic diseases (E70-E88)")
• Type 2 Excludes: G71 Primary disorders of muscles ("metabolic disorders (E70-E88)")
• Code First: G99.0 Autonomic neuropathy in diseases classified elsewhere ("amyloidosis (E85.-)")
• Code First: G99.8 Other specified disorders of nervous system in diseases classified elsewhere ("amyloidosis (E85.-)")
• Code First: H42 Glaucoma in diseases classified elsewhere ("amyloidosis (E85.-)")
• Code First: H42 Glaucoma in diseases classified elsewhere ("specified metabolic disorder (E70-E88)")
• Code First: I43 Cardiomyopathy in diseases classified elsewhere ("amyloidosis (E85.-)")
• Code First: I68.0 Cerebral amyloid angiopathy ("underlying amyloidosis (E85.-)")
• Code First: I79.8 Other disorders of arteries, arterioles and capillaries in diseases classified elsewhere ("amyloidosis (E85.-)")
• Code First: J99 Respiratory disorders in diseases classified elsewhere ("amyloidosis (E85.-)")
• Type 2 Excludes: K76 Other diseases of liver ("amyloid degeneration of liver (E85.-)")
• Code First: K77 Liver disorders in diseases classified elsewhere ("amyloidosis (E85.-)")
• Code First: L99 Other disorders of skin and subcutaneous tissue in diseases classified elsewhere ("amyloidosis (E85.-)")
• Code First: M14.8 Arthropathies in other specified diseases classified elsewhere ("amyloidosis (E85.-)")
• Type 2 Excludes: N07 Hereditary nephropathy, not elsewhere classified ("hereditary amyloid nephropathy (E85.-)")
• Type 2 Excludes: N07 Hereditary nephropathy, not elsewhere classified ("non-neuropathic heredofamilial amyloidosis (E85.-)")
• Code First: N08 Glomerular disorders in diseases classified elsewhere ("amyloidosis (E85.-)")
• Type 2 Excludes: N25.0 Renal osteodystrophy ("metabolic disorders classifiable to E70-E88")
• Type 2 Excludes: N25.81 Secondary hyperparathyroidism of renal origin ("metabolic disorders classifiable to E70-E88")
• Code First: N29 Other disorders of kidney and ureter in diseases classified elsewhere ("amyloidosis (E85.-)")
• Type 1 Excludes: P59 Neonatal jaundice from other and unspecified causes ("jaundice due to inborn errors of metabolism (E70-E88)")

Diagnosis Index entries for E85.82

• Amyloidosis (generalized) (primary) › senile systemic (SSA)
• Amyloidosis (generalized) (primary) › wild-type transthyretin-related (ATTR)

Nearby codes

• E85.2 Heredofamilial amyloidosis, unspecified
• E85.3 Secondary systemic amyloidosis
• E85.4 Organ-limited amyloidosis
• E85.8 Other amyloidosis
• E85.81 Light chain (AL) amyloidosis
• E85.82 Wild-type transthyretin-related (ATTR) amyloidosis (this code)
• E85.89 Other amyloidosis
• E85.9 Amyloidosis, unspecified