`E88.82` Obesity due to disruption of MC4R pathway

Billable ICD-10-CM code, FY2026.

code, if applicable, to identify associated manifestations, such as polyphagia (R63.2)
code to identify body mass index (BMI), if known (Z68.-)

MS-DRG index

Defines the logic of DRG(s) 642 in MDC 10.

Type 2 Excludes: G11 Hereditary ataxia ("metabolic disorders (E70-E88)")
Code First: G63 Polyneuropathy in diseases classified elsewhere ("metabolic diseases (E70-E88)")
Type 2 Excludes: G71 Primary disorders of muscles ("metabolic disorders (E70-E88)")
Code First: H42 Glaucoma in diseases classified elsewhere ("specified metabolic disorder (E70-E88)")
Type 2 Excludes: N25.0 Renal osteodystrophy ("metabolic disorders classifiable to E70-E88")
Type 2 Excludes: N25.81 Secondary hyperparathyroidism of renal origin ("metabolic disorders classifiable to E70-E88")
Type 1 Excludes: P59 Neonatal jaundice from other and unspecified causes ("jaundice due to inborn errors of metabolism (E70-E88)")

Obesity › due to › disruption of MC4R pathway
Obesity › due to › gene mutation › leptin (LEP)
Obesity › due to › gene mutation › leptin receptor (LEPR)
Obesity › due to › gene mutation › melanocortin 4 Receptor (MC4R)
Obesity › due to › gene mutation › nuclear receptor coactivator 1 (NCOA1)
Obesity › due to › gene mutation › proopiomelanocortin (POMC)
Obesity › due to › gene mutation › proprotein convertase subtilisin/kexin type 1 (PCSK1)
Obesity › due to › gene mutation › src homology 2B adaptor signaling protein (SH2B1)